Entry |
|
Name |
Codeine hydrochloride; Bisoltus (TN) |
Formula |
C18H22NO3. Cl
|
Exact mass |
335.1288
|
Mol weight |
335.82
|
Structure |
|
Simcomp |
|
Class |
|
Remark |
Product (DG01076): | D02101<JP> D03580<US> |
|
Efficacy |
Analgesic (narcotic), Antitussive, Narcotic, Opioid receptor agonist |
Comment |
Opium alkaloid
Active form of prodrug: Morphine [DR: D08233]
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
Interaction |
|
Structure map |
map07224 | Opioid receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA04 Codeine
D07740 Codeine hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
D07740 Codeine hydrochloride
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
D07740 Codeine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
D07740 Codeine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
D07740 Codeine hydrochloride
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
D07740 Codeine hydrochloride
DG03190 UGT2B7 substrate
DG01076 Codeine
D07740 Codeine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D07740 Codeine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07740
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
DG03190 UGT2B7 substrate
DG01076 Codeine
Prodrugs [br08324.html]
DG01076
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 23
1 C1z C 17.6971 -16.7898
2 C8y C 17.6971 -15.5305
3 C1y C 18.8165 -17.4894
4 C1y C 16.5777 -17.4894
5 C1x C 18.8865 -16.1602
6 C8y C 16.5777 -14.8309
7 C8y C 18.8865 -14.8309
8 C1y C 20.0058 -16.7898
9 C2x C 18.8165 -18.7487
10 O2x O 15.2485 -16.0902
11 C1y C 16.5777 -18.7487
12 C1x C 21.1952 -16.1602
13 C8y C 16.5777 -13.5016
14 C1x C 20.0058 -15.5305
15 C8x C 18.8865 -13.5016
16 N2y N 21.1952 -17.4894 #+
17 C2x C 17.6971 -19.4483
18 O1a O 15.4583 -19.4483
19 C8x C 17.6971 -12.8720
20 O2a O 15.4583 -12.8720
21 C1a C 14.3390 -13.5016
22 C1a C 22.5245 -17.4894
23 X Cl 22.9442 -14.2012 #-
BOND 26
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 1 #Down
10 4 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 8 16 1 #Up
16 9 17 2
17 11 18 1 #Down
18 13 19 2
19 13 20 1
20 20 21 1
21 6 10 1
22 8 14 1
23 11 17 1
24 12 16 1
25 15 19 1
26 16 22 1
|