| Entry |
|
|---|
| Name |
Dosulepin (INN);
Dothiepin;
Dothep (TN) |
|---|
| Formula |
C19H21NS
|
|---|
| Exact mass |
295.1395
|
|---|
| Mol weight |
295.44
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00940): | D01546<JP> |
|
|---|
| Efficacy |
Antidepressant |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA16 Dosulepin
D07872 Dosulepin (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00940 Dosulepin
D07872 Dosulepin
DG01728 Tricyclic antidepressant
DG00940 Dosulepin
D07872 Dosulepin
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00940 Dosulepin
D07872 Dosulepin
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D07872 Dosulepin (INN)
SLC6A4 (HTT)
D07872 Dosulepin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07872
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00940 Dosulepin
DG01728 Tricyclic antidepressant
DG00940 Dosulepin
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00940 Dosulepin
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 21
1 C1x C 21.9800 -21.2100
2 C8y C 21.1400 -20.0900
3 C8y C 21.4200 -18.6900
4 C2y C 22.6800 -18.1300
5 S2x S 23.3800 -21.2100
6 C8y C 23.9400 -18.7600
7 C8y C 24.2900 -20.1600
8 C8x C 20.4400 -17.7100
9 C8x C 19.1100 -18.1300
10 C8x C 18.7600 -19.4600
11 C8x C 19.7400 -20.4400
12 C8x C 25.6200 -20.5800
13 C8x C 26.6700 -19.6000
14 C8x C 26.3200 -18.2700
15 C8x C 24.9900 -17.8500
16 C2b C 22.6800 -16.7300
17 C1b C 23.8700 -16.1000
18 C1b C 25.0600 -16.8000
19 N1c N 26.3200 -16.1000
20 C1a C 27.5100 -16.8000
21 C1a C 26.3200 -14.7000
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 19 21 1
|
|---|
