KEGG T01001: 6532

Homo sapiens (human): 6532

Entry

6532              CDS       T01001

Symbol

SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT

Name

(RefSeq) solute carrier family 6 member 4

K05037

solute carrier family 6 (neurotransmitter transporter, serotonin) member 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04082

Neuroactive ligand signaling

hsa04721

Synaptic vesicle cycle

hsa04726

Serotonergic synapse

Network

nt06544 Neuroactive ligand signaling

Element

N01902

Transport of serotonin, SLC6A4

Disease

H01450

Obsessive-compulsive disorder

Drug target

Alaproclate:

D02787

Amitifadine (DG01386):

D10088 D10089

Amitriptyline (DG00934):

D00809<JP/US> D07448

Amitriptylinoxide:

D07449

Amoxapine:

D00228<JP/US>

Ampreloxetine (DG03081):

D11688 D11689

Centanafadine (DG01858):

D10697 D10698

Cidoxepin hydrochloride:

D03491

Citalopram (DG00943):

D00822<US> D07704 D07705

Clomipramine (DG00929):

D00811<JP/US> D07727

Cocaine (DG00808):

D00110 D02182<US>

Dapoxetine:

D03649

Desipramine (DG00927):

D00812<US> D07791

Desvenlafaxine (DG00963):

D02570<US> D07793<US> D11619

Dexfenfluramine (DG00105):

D03713 D07805

Dexmethylphenidate (DG00972):

D03721<US> D07806

Dosulepin (DG00940):

D01546<JP> D07872

Doxepin (DG00937):

D00814<US> D07875

Duloxetine (DG00962):

D01179<JP/US> D07880

Escitalopram (DG00947):

D02567<JP/US> D07913

Fenfluramine (DG00103):

D04148<JP/US> D07945

Fluoxetine (DG00942):

D00326 D00823<US>

Fluvoxamine (DG00946):

D00824<JP/US> D07984

Imipramine (DG00928):

D00815<JP/US> D08070 D08071<US>

Imipraminoxide (DG01542):

D07334 D08072

Indeloxazine (DG02869):

D02170 D08077

Levomilnacipran (DG01387):

D10072 D10133<US>

Liafensine:

D10443

Lofepramine (DG00932):

D01285 D08140

Lubazodone hydrochloride:

D04788

Mazindol:

D00367<JP>

Metamfetamine (DG00968):

D02242<JP/US> D08187

Midomafetamine (DG03316):

D11172 D12937

Milnacipran (DG00960):

D01107<JP/US> D08222

Nortriptyline (DG00935):

D00816<JP/US> D08288

Paroxetine (DG00944):

D02260<JP/US> D02362 D05374<US> D05375<US>

Phentermine (DG00102):

D05458 D05459<US>

Pirandamine hydrochloride:

D05491

Protriptyline (DG00936):

D00484<US> D08447

Sertraline (DG00945):

D00825<JP/US> D02360

Sibutramine (DG00108):

D02571 D08513

Tenamfetamine:

D12715

Toludesvenlafaxine (DG03141):

D11940 D11941

Trazodone (DG00952):

D00820<JP/US> D08626

Trimipramine (DG00931):

D00394 D02408<JP/US>

Venlafaxine (DG00959):

D00821<JP/US> D08670 D12403<US>

Vilazodone (DG00964):

D09698 D09699<US>

Vortioxetine (DG00965):

D10184 D10185<JP/US> D12544

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    6532 (SLC6A4)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    6532 (SLC6A4)
   04721 Synaptic vesicle cycle
    6532 (SLC6A4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6532 (SLC6A4)
Transporters [BR:hsa02000]
Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6532 (SLC6A4)

SSDB

Motif

Pfam:

SNF 5HT_transport_N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(30194319..30235697)

AA seq 630 aa
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV

NT seq 1893 nt +upstreamnt +downstreamnt
atggagacgacgcccttgaattctcagaagcagctatcagcgtgtgaagatggagaagat
tgtcaggaaaacggagttctacagaaggttgttcccaccccaggggacaaagtggagtcc
gggcaaatatccaatgggtactcagcagttccaagtcctggtgcgggagatgacacacgg
cactctatcccagcgaccaccaccaccctagtggctgagcttcatcaaggggaacgggag
acctggggcaagaaggtggatttccttctctcagtgattggctatgctgtggacctgggc
aatgtctggcgcttcccctacatatgttaccagaatggagggggggcattcctcctcccc
tacaccatcatggccatttttgggggaatcccgctcttttacatggagctcgcactggga
cagtaccaccgaaatggatgcatttcaatatggaggaaaatctgcccgattttcaaaggg
attggttatgccatctgcatcattgccttttacattgcttcctactacaacaccatcatg
gcctgggcgctatactacctcatctcctccttcacggaccagctgccctggaccagctgc
aagaactcctggaacactggcaactgcaccaattacttctccgaggacaacatcacctgg
accctccattccacgtcccctgctgaagaattttacacgcgccacgtcctgcagatccac
cggtctaaggggctccaggacctggggggcatcagctggcagctggccctctgcatcatg
ctgatcttcactgttatctacttcagcatctggaaaggcgtcaagacctctggcaaggtg
gtgtgggtgacagccaccttcccttatatcatcctttctgtcctgctggtgaggggtgcc
accctccctggagcctggaggggtgttctcttctacttgaaacccaattggcagaaactc
ctggagacaggggtgtggatagatgcagccgctcagatcttcttctctcttggtccgggc
tttggggtcctgctggcttttgctagctacaacaagttcaacaacaactgctaccaagat
gccctggtgaccagcgtggtgaactgcatgacgagcttcgtttcgggatttgtcatcttc
acagtgctcggttacatggctgagatgaggaatgaagatgtgtctgaggtggccaaagac
gcaggtcccagcctcctcttcatcacgtatgcagaagcgatagccaacatgccagcgtcc
actttctttgccatcatcttctttctgatgttaatcacgctgggcttggacagcacgttt
gcaggcttggagggggtgatcacggctgtgctggatgagttcccacacgtctgggccaag
cgccgggagcggttcgtgctcgccgtggtcatcacctgcttctttggatccctggtcacc
ctgacttttggaggggcctacgtggtgaagctgctggaggagtatgccacggggcccgca
gtgctcactgtcgcgctgatcgaagcagtcgctgtgtcttggttctatggcatcactcag
ttctgcagggacgtgaaggaaatgctcggcttcagcccggggtggttctggaggatctgc
tgggtggccatcagccctctgtttctcctgttcatcatttgcagttttctgatgagcccg
ccacaactacgacttttccaatataattatccttactggagtatcatcttgggttactgc
ataggaacctcatctttcatttgcatccccacatatatagcttatcggttgatcatcact
ccagggacatttaaagagcgtattattaaaagtattaccccagaaacaccaacagaaatt
ccttgtggggacatccgcttgaatgctgtgtaa

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