KEGG   DRUG: HydralazineHelp
Entry
D08044                      Drug                                   

Name
Hydralazine (INN);
Hidral (TN)
Formula
C8H8N4
Exact mass
160.0749
Mol weight
160.1759
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG02046  Hydrazinophthalazine derivative
Enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C07040
ATC code: C02DB02
Chemical structure group: DG00261
Product (DG00261): D01302<JP/US>
Efficacy
Antihypertensive, Vasodilator (peripheric)
Comment
Hydrazinophthalazine derivative
Target
AOC3 [HSA:8639] [KO:K00276]
Metabolism
Enzyme: NAT [HSA:9 10]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DB Hydrazinophthalazine derivatives
     C02DB02 Hydralazine
      D08044  Hydralazine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators, Direct-acting Arterial
   Hydralazine
    D08044  Hydralazine (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    AOC3
     D08044  Hydralazine (INN)
BRITE hierarchy
Other DBs
CAS: 86-54-4
PubChem: 96024737
ChEBI: 5775
ChEMBL: CHEMBL276832
DrugBank: DB01275
PDB-CCD: HLZ[PDBj]
LigandBox: D08044
NIKKAJI: J4.262E
LinkDB All DBs
KCF data Show

ATOM        12
            1   C8y C    24.1500  -18.2700
            2   C8y C    24.1500  -19.6700
            3   C8y C    25.3400  -17.6400
            4   C8x C    22.8900  -17.5700
            5   C8x C    25.3400  -20.3700
            6   C8x C    22.8900  -20.3700
            7   N4x N    26.5300  -18.3400
            8   N2b N    25.3400  -16.2400
            9   C8x C    21.7000  -18.2700
            10  N5x N    26.5300  -19.7400
            11  C8x C    21.7000  -19.6700
            12  N1a N    26.6000  -15.5400
BOND        13
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9     5  10 2
            10    6  11 2
            11    8  12 1
            12    7  10 1
            13    9  11 1

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