KEGG   DRUG: Hydralazine
Entry
D08044                      Drug                                   
Name
Hydralazine (INN);
Hidral (TN)
Formula
C8H8N4
Exact mass
160.0749
Mol weight
160.18
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
 DG02046  Hydrazinophthalazine derivative
Metabolizing enzyme substrate
 DG02928  NAT substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C07040
ATC code: C02DB02
Chemical structure group: DG00261
Product (DG00261): D01302<JP/US>
Efficacy
Antihypertensive, Vasodilator (peripheric)
Comment
Hydrazinophthalazine derivative
Target
AOC3 [HSA:8639] [KO:K00276]
Metabolism
Enzyme: NAT [HSA:9 10]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DB Hydrazinophthalazine derivatives
     C02DB02 Hydralazine
      D08044  Hydralazine (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG00261  Hydralazine
    D08044  Hydralazine
  DG02046  Hydrazinophthalazine derivative
   DG00261  Hydralazine
    D08044  Hydralazine
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG00261  Hydralazine
    D08044  Hydralazine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00261  Hydralazine
    D08044  Hydralazine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    AOC3
     D08044  Hydralazine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08044
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG00261  Hydralazine
  DG02046  Hydrazinophthalazine derivative
   DG00261  Hydralazine
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG00261  Hydralazine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00261  Hydralazine
Other DBs
CAS: 86-54-4
PubChem: 96024737
ChEBI: 5775
PDB-CCD: HLZ[PDBj]
LigandBox: D08044
NIKKAJI: J4.262E
LinkDB
KCF data

ATOM        12
            1   C8y C    24.1500  -18.2700
            2   C8y C    24.1500  -19.6700
            3   C8y C    25.3400  -17.6400
            4   C8x C    22.8900  -17.5700
            5   C8x C    25.3400  -20.3700
            6   C8x C    22.8900  -20.3700
            7   N4x N    26.5300  -18.3400
            8   N2b N    25.3400  -16.2400
            9   C8x C    21.7000  -18.2700
            10  N5x N    26.5300  -19.7400
            11  C8x C    21.7000  -19.6700
            12  N1a N    26.6000  -15.5400
BOND        13
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9     5  10 2
            10    6  11 2
            11    8  12 1
            12    7  10 1
            13    9  11 1

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