| Entry |
|
|---|
| Name |
Lofepramine (INN) |
|---|
| Formula |
C26H27ClN2O
|
|---|
| Exact mass |
418.1812
|
|---|
| Mol weight |
418.96
|
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| Structure |
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
|
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| Remark |
| Product (DG00932): | D01285<JP> |
|
|---|
| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
|---|
| Target |
|
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| Pathway |
|
|---|
| Interaction |
|
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA07 Lofepramine
D08140 Lofepramine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00932 Lofepramine
D08140 Lofepramine
DG01728 Tricyclic antidepressant
DG00932 Lofepramine
D08140 Lofepramine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D08140 Lofepramine (INN)
SLC6A4 (HTT)
D08140 Lofepramine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00932 Lofepramine
DG01728 Tricyclic antidepressant
DG00932 Lofepramine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 C1x C 19.9500 -21.2100
2 C8y C 19.1100 -20.0900
3 C8y C 19.4600 -18.7600
4 N1y N 20.7200 -18.2000
5 C1x C 21.3500 -21.2100
6 C8y C 21.9800 -18.8300
7 C8y C 22.2600 -20.1600
8 C8x C 18.4100 -17.7800
9 C8x C 17.0800 -18.2000
10 C8x C 16.7300 -19.5300
11 C8x C 17.7800 -20.5100
12 C8x C 23.5900 -20.5800
13 C8x C 24.6400 -19.6700
14 C8x C 24.3600 -18.2700
15 C8x C 23.0300 -17.8500
16 C1b C 20.7200 -16.8000
17 C1b C 21.9100 -16.1000
18 C1b C 23.1000 -16.7300
19 N1c N 24.2900 -16.1000
20 C1b C 25.5500 -16.7300
21 C5a C 26.7400 -16.1000
22 C8y C 27.9300 -16.7300
23 O5a O 26.7400 -14.6300
24 C1a C 24.2900 -14.6300
25 C8x C 27.9300 -18.2000
26 C8x C 29.1200 -18.9000
27 C8y C 30.3100 -18.2000
28 C8x C 30.3100 -16.7300
29 C8x C 29.1200 -16.0300
30 X Cl 31.5700 -18.9000
BOND 33
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 21 23 2
26 19 24 1
27 22 25 2
28 25 26 1
29 26 27 2
30 27 28 1
31 28 29 2
32 22 29 1
33 27 30 1
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