| Entry |
|
|---|
| Name |
Manidipine (INN);
Manidipine 6300;
Artedil (TN) |
|---|
| Formula |
C35H38N4O6
|
|---|
| Exact mass |
610.2791
|
|---|
| Mol weight |
610.70
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00324): | D01553<JP> |
|
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| Efficacy |
Antihypertensive, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA11 Manidipine
D08155 Manidipine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00324 Manidipine
D08155 Manidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00324 Manidipine
D08155 Manidipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00324 Manidipine
D08155 Manidipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D08155 Manidipine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08155
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00324 Manidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00324 Manidipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00324 Manidipine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 45
1 C8x C 18.1300 -19.6700
2 C8x C 18.1300 -18.2700
3 C8y C 19.3900 -17.5700
4 C8x C 20.5800 -18.2700
5 C8y C 20.5800 -19.6700
6 C8x C 19.3900 -20.3700
7 C1y C 19.3900 -16.1700
8 C2y C 18.1300 -15.4700
9 C2y C 18.1300 -14.0700
10 N1x N 19.3900 -13.3700
11 C2y C 20.5800 -14.0700
12 C2y C 20.5800 -15.4700
13 C7a C 21.7700 -16.1700
14 O7a O 23.0300 -15.4700
15 C1b C 24.2200 -16.1700
16 C1b C 25.4100 -15.4700
17 N1y N 26.6700 -16.1700
18 C1x C 27.8600 -15.4700
19 C1x C 29.0500 -16.1700
20 N1y N 29.0500 -17.5700
21 C1x C 27.8600 -18.2700
22 C1x C 26.6700 -17.5700
23 O6a O 21.7700 -17.5700
24 C1c C 30.3100 -18.2700
25 C8y C 31.5000 -17.5700
26 C8y C 30.3100 -19.6700
27 C8x C 31.5000 -20.3700
28 C8x C 31.5000 -21.7700
29 C8x C 30.2400 -22.4700
30 C8x C 29.0500 -21.7700
31 C8x C 29.0500 -20.3700
32 C8x C 31.5000 -16.1700
33 C8x C 32.6900 -15.4700
34 C8x C 33.8800 -16.1700
35 C8x C 33.8800 -17.5700
36 C8x C 32.6900 -18.2700
37 C1a C 21.7700 -13.3700
38 C1a C 16.9400 -13.3700
39 C7a C 16.9400 -16.1700
40 O6a O 16.9400 -17.5700
41 O7a O 15.7500 -15.4700
42 C1a C 14.4900 -16.1700
43 N2b N 21.7700 -20.3700 #+
44 O3a O 23.0300 -19.6700
45 O3a O 21.7700 -21.7700 #-
BOND 49
1 21 22 1
2 22 17 1
3 7 8 1
4 13 23 2
5 8 9 2
6 20 24 1
7 9 10 1
8 24 25 1
9 10 11 1
10 24 26 1
11 11 12 2
12 12 7 1
13 4 5 1
14 12 13 1
15 5 6 2
16 26 27 2
17 27 28 1
18 28 29 2
19 29 30 1
20 30 31 2
21 31 26 1
22 13 14 1
23 6 1 1
24 14 15 1
25 15 16 1
26 25 32 2
27 32 33 1
28 33 34 2
29 34 35 1
30 35 36 2
31 36 25 1
32 3 7 1
33 11 37 1
34 16 17 1
35 9 38 1
36 8 39 1
37 39 40 2
38 1 2 2
39 39 41 1
40 2 3 1
41 41 42 1
42 3 4 2
43 5 43 1
44 17 18 1
45 43 44 2
46 18 19 1
47 43 45 1
48 19 20 1
49 20 21 1
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