KEGG   DRUG: PilsicainideHelp
Entry
D08377                      Drug                                   

Name
Pilsicainide (INN)
Formula
C17H24N2O
Exact mass
272.1889
Mol weight
272.3853
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Transporter inhibitor
 DG02863  SLC22A2 (OCT2) inhibitor
Remark
Chemical structure group: DG01257
Product (DG01257): D01554<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ic)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08377  Pilsicainide (INN)
    SCN2A
     D08377  Pilsicainide (INN)
    SCN3A
     D08377  Pilsicainide (INN)
    SCN4A
     D08377  Pilsicainide (INN)
    SCN5A
     D08377  Pilsicainide (INN)
    SCN8A
     D08377  Pilsicainide (INN)
    SCN9A
     D08377  Pilsicainide (INN)
    SCN10A
     D08377  Pilsicainide (INN)
    SCN11A
     D08377  Pilsicainide (INN)
BRITE hierarchy
Other DBs
CAS: 88069-67-4
PubChem: 96025063
ChEMBL: CHEMBL163238
LigandBox: D08377
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8y C    25.8300  -17.0100
            2   C8y C    27.0200  -17.7100
            3   C8x C    28.2800  -17.0100
            4   C8x C    28.2800  -15.6100
            5   C8x C    27.0200  -14.9100
            6   C8y C    25.8300  -15.6100
            7   N1y N    22.1900  -20.5100
            8   C1z C    22.1900  -19.1100
            9   C1x C    23.5200  -20.9300
            10  C1x C    20.8600  -20.9300
            11  C1x C    23.5200  -18.6200
            12  C1x C    20.8600  -18.6200
            13  C1x C    24.3600  -19.8100
            14  C1x C    20.0200  -19.8100
            15  C1b C    22.1900  -17.7100
            16  C5a C    23.3800  -17.0100
            17  O5a O    23.3800  -15.6100
            18  N1b N    24.6400  -17.7100
            19  C1a C    24.6400  -14.9100
            20  C1a C    27.0200  -19.1100
BOND        22
            1     6   1 1
            2     7   8 1
            3     7   9 1
            4     7  10 1
            5     8  11 1
            6     8  12 1
            7     9  13 1
            8    10  14 1
            9    11  13 1
            10   12  14 1
            11    8  15 1
            12   15  16 1
            13    1   2 2
            14   16  17 2
            15    2   3 1
            16   16  18 1
            17   18   1 1
            18    3   4 2
            19    6  19 1
            20    4   5 1
            21    2  20 1
            22    5   6 2

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