KEGG   DRUG: Pilsicainide
Entry
D08377                      Drug                                   
Name
Pilsicainide (INN)
Formula
C17H24N2O
Exact mass
272.1889
Mol weight
272.3853
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Remark
Chemical structure group: DG01257
Product (DG01257): D01554<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ic)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG01257  Pilsicainide
      D08377  Pilsicainide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08377  Pilsicainide (INN)
    SCN2A
     D08377  Pilsicainide (INN)
    SCN3A
     D08377  Pilsicainide (INN)
    SCN4A
     D08377  Pilsicainide (INN)
    SCN5A
     D08377  Pilsicainide (INN)
    SCN8A
     D08377  Pilsicainide (INN)
    SCN9A
     D08377  Pilsicainide (INN)
    SCN10A
     D08377  Pilsicainide (INN)
    SCN11A
     D08377  Pilsicainide (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG01257  Pilsicainide
Other DBs
CAS: 88069-67-4
PubChem: 96025063
ChEBI: 135127
LigandBox: D08377
LinkDB
KCF data

ATOM        20
            1   C8y C    25.8300  -17.0100
            2   C8y C    27.0200  -17.7100
            3   C8x C    28.2800  -17.0100
            4   C8x C    28.2800  -15.6100
            5   C8x C    27.0200  -14.9100
            6   C8y C    25.8300  -15.6100
            7   N1y N    22.1900  -20.5100
            8   C1z C    22.1900  -19.1100
            9   C1x C    23.5200  -20.9300
            10  C1x C    20.8600  -20.9300
            11  C1x C    23.5200  -18.6200
            12  C1x C    20.8600  -18.6200
            13  C1x C    24.3600  -19.8100
            14  C1x C    20.0200  -19.8100
            15  C1b C    22.1900  -17.7100
            16  C5a C    23.3800  -17.0100
            17  O5a O    23.3800  -15.6100
            18  N1b N    24.6400  -17.7100
            19  C1a C    24.6400  -14.9100
            20  C1a C    27.0200  -19.1100
BOND        22
            1     6   1 1
            2     7   8 1
            3     7   9 1
            4     7  10 1
            5     8  11 1
            6     8  12 1
            7     9  13 1
            8    10  14 1
            9    11  13 1
            10   12  14 1
            11    8  15 1
            12   15  16 1
            13    1   2 2
            14   16  17 2
            15    2   3 1
            16   16  18 1
            17   18   1 1
            18    3   4 2
            19    6  19 1
            20    4   5 1
            21    2  20 1
            22    5   6 2

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KEGG   DRUG: Pilsicainide hydrochloride hydrate
Entry
D01554                      Drug                                   
Name
Pilsicainide hydrochloride hydrate (JP18);
Pilsicainide hydrochloride;
SUN 1165 (TN);
Sunrythm (TN)
Formula
(C17H24N2O. HCl)2. H2O
Exact mass
634.3416
Mol weight
635.7077
Structure
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Remark
Therapeutic category: 2129
Chemical structure group: DG01257
Product (DG01257): D01554<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ic)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01554  Pilsicainide hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG01257  Pilsicainide
      D01554  Pilsicainide hydrochloride hydrate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D01554  Pilsicainide hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN2A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN3A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN4A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN5A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN8A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN9A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN10A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
    SCN11A
     D01554  Pilsicainide hydrochloride hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01554  Pilsicainide hydrochloride hydrate
  D01554  Pilsicainide hydrochloride capsules
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG01257  Pilsicainide
Other DBs
PubChem: 7848617
ChEBI: 32001
LigandBox: D01554
LinkDB
KCF data

ATOM        43
            1   C8y C    23.4457  -28.8068
            2   C8y C    24.6550  -29.5069
            3   C8x C    25.8660  -28.8097
            4   C8x C    25.8677  -27.4122
            5   C8x C    24.6583  -26.7120
            6   C8y C    23.4474  -27.4093
            7   N1y N    19.8148  -32.3137
            8   C1z C    19.8089  -30.9148
            9   C1x C    21.1432  -32.7408
            10  C1x C    18.4804  -32.7525
            11  C1x C    21.1374  -30.4759
            12  C1x C    18.4745  -30.4817
            13  C1x C    21.9626  -31.6054
            14  C1x C    17.6493  -31.6231
            15  C1b C    19.8084  -29.5146
            16  C5a C    21.0206  -28.8139
            17  O5a O    21.0203  -27.4136
            18  N1b N    22.2335  -29.5137
            19  C1a C    22.2355  -26.7078
            20  C1a C    24.6533  -30.9072
            21  X   Cl   28.7396  -30.5199
            22  O0  O    33.2503  -29.1903
            23  C8y C    23.4457  -28.8068
            24  C8y C    23.4474  -27.4093
            25  C1a C    22.2355  -26.7078
            26  C8x C    24.6583  -26.7120
            27  C8x C    25.8677  -27.4122
            28  C8x C    25.8660  -28.8097
            29  C8y C    24.6550  -29.5069
            30  C1a C    24.6533  -30.9072
            31  N1b N    22.2335  -29.5137
            32  C5a C    21.0206  -28.8139
            33  C1b C    19.8084  -29.5146
            34  C1z C    19.8089  -30.9148
            35  N1y N    19.8148  -32.3137
            36  C1x C    21.1432  -32.7408
            37  C1x C    21.9626  -31.6054
            38  C1x C    21.1374  -30.4759
            39  C1x C    18.4804  -32.7525
            40  C1x C    17.6493  -31.6231
            41  C1x C    18.4745  -30.4817
            42  O5a O    21.0203  -27.4136
            43  X   Cl   28.7396  -30.5199
BOND        44
            1     6   1 1
            2     7   8 1
            3     7   9 1
            4     7  10 1
            5     8  11 1
            6     8  12 1
            7     9  13 1
            8    10  14 1
            9    11  13 1
            10   12  14 1
            11    8  15 1
            12   15  16 1
            13    1   2 2
            14   16  17 2
            15    2   3 1
            16   16  18 1
            17   18   1 1
            18    3   4 2
            19    6  19 1
            20    4   5 1
            21    2  20 1
            22    5   6 2
            23   24  23 1
            24   35  34 1
            25   35  36 1
            26   35  39 1
            27   34  38 1
            28   34  41 1
            29   36  37 1
            30   39  40 1
            31   38  37 1
            32   41  40 1
            33   34  33 1
            34   33  32 1
            35   23  29 2
            36   32  42 2
            37   29  28 1
            38   32  31 1
            39   31  23 1
            40   28  27 2
            41   24  25 1
            42   27  26 1
            43   29  30 1
            44   26  24 2
BRACKET     1    17.0100  -33.2500   17.0100  -25.4100
            1    30.1000  -25.4100   30.1000  -33.2500
            1  2
 ORIGINAL  1    1   6  19   5   4   3   2  20  18  16  15   8   7   9  13  11
            1   10  14  12  17  21
 REPEAT    1   23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38
            1   39  40  41  42  43

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