KEGG   DRUG: Pirmenol
Entry
D08394                      Drug                                   
Name
Pirmenol (INN)
Formula
C22H30N2O
Exact mass
338.2358
Mol weight
338.4864
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Remark
Chemical structure group: DG01381
Product (DG01381): D01785<JP>
Efficacy
Antiarrhythmic
Comment
Class I antiarrhythmic agent (Ia)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
      D08394  Pirmenol
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08394  Pirmenol (INN)
    SCN2A
     D08394  Pirmenol (INN)
    SCN3A
     D08394  Pirmenol (INN)
    SCN4A
     D08394  Pirmenol (INN)
    SCN5A
     D08394  Pirmenol (INN)
    SCN8A
     D08394  Pirmenol (INN)
    SCN9A
     D08394  Pirmenol (INN)
    SCN10A
     D08394  Pirmenol (INN)
    SCN11A
     D08394  Pirmenol (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG01381  Pirmenol
Other DBs
CAS: 68252-19-7
PubChem: 96025080
ChEBI: 135436
LigandBox: D08394
NIKKAJI: J252.795B
LinkDB
KCF data

ATOM        25
            1   C8x C    19.9500  -20.3700
            2   C8x C    19.9500  -21.7700
            3   C8x C    21.1400  -22.4700
            4   C8x C    22.3300  -21.7700
            5   C8y C    22.3300  -20.3700
            6   C8x C    21.1400  -19.6700
            7   C1d C    23.5900  -19.6700
            8   C8y C    24.7800  -20.3700
            9   C8x C    24.7800  -21.7700
            10  C8x C    25.9700  -22.4700
            11  C8x C    27.2300  -21.7700
            12  C8x C    27.2300  -20.3700
            13  N5x N    25.9700  -19.6700
            14  C1b C    23.5900  -18.2700
            15  C1b C    24.7800  -17.5700
            16  C1b C    24.7800  -16.1700
            17  N1y N    25.9700  -15.4700
            18  C1y C    27.2300  -16.1700
            19  C1x C    28.4200  -15.4700
            20  C1x C    28.4200  -14.0700
            21  C1x C    27.2300  -13.3700
            22  C1y C    25.9700  -14.0700
            23  C1a C    24.7800  -13.3700
            24  C1a C    27.2300  -17.5700
            25  O1a O    22.4000  -18.9700
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

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