KEGG   DRUG: RabeprazoleHelp
Entry
D08463                      Drug                                   

Name
Rabeprazole (INN);
Eraloc (TN)
Formula
C18H21N3O3S
Exact mass
359.1304
Mol weight
359.4426
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01646  Proton pump inhibitor (PPI)
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07864
ATC code: A02BC04
Chemical structure group: DG00022
Product (DG00022): D00724<JP/US>
Product (mixture): D10519<JP>
Efficacy
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor
Comment
Benzimidazole derivative
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07038  Antiulcer drugs
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D08463  Rabeprazole (INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Rabeprazole
    D08463  Rabeprazole (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D08463  Rabeprazole (INN)
BRITE hierarchy
Other DBs
CAS: 117976-89-3
PubChem: 96025149
ChEBI: 8768
ChEMBL: CHEMBL1219
DrugBank: DB01129
LigandBox: D08463
NIKKAJI: J395.966J
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C    16.8700  -17.6400
            2   C8x C    16.8700  -19.0400
            3   C8x C    18.0600  -19.7400
            4   C8y C    19.2500  -19.0400
            5   C8y C    19.2500  -17.6400
            6   C8x C    18.0600  -16.9400
            7   N5x N    20.5800  -19.4600
            8   C8y C    21.4200  -18.3400
            9   N4x N    20.5800  -17.2200
            10  S4a S    22.8200  -18.3400
            11  C1b C    23.5200  -19.6000
            12  O3c O    23.5200  -17.1500
            13  C8y C    24.9200  -19.6000
            14  C8y C    25.6200  -20.7900
            15  C8y C    27.0200  -20.7900
            16  C8x C    27.7200  -19.5300
            17  C8x C    27.0200  -18.3400
            18  N5x N    25.6200  -18.3400
            19  C1a C    24.9200  -21.9800
            20  O2a O    27.7200  -21.9800
            21  C1b C    29.1200  -21.9800
            22  C1b C    29.8200  -23.1700
            23  C1b C    31.2200  -23.1700
            24  O2a O    31.9200  -24.3600
            25  C1a C    33.3200  -24.3600
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 2
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1

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