KEGG   DRUG: RasagilineHelp
Entry
D08469                      Drug                                   

Name
Rasagiline (USAN/INN);
Azilect (TN)
Formula
C12H13N
Exact mass
171.1048
Mol weight
171.2383
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01512  Monoamine oxidase B inhibitor
 DG01967  Antiparkinson agent
Enzyme substrate
 DG01892  CYP1A2 substrate
Remark
ATC code: N04BD02
Chemical structure group: DG00865
Product (DG00865): D02562<JP/US>
Efficacy
Antiparkinsonian, Neuroprotectant, Monoamine oxidase B (MAO-B) inhibitor
Comment
Treatment of Parkinson's disease
Target
MAOB [HSA:4129] [KO:K00274]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
map07057  Antiparkinsonian agents
map07216  Catecholamine transferase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BD Monoamine oxidase B inhibitors
     N04BD02 Rasagiline
      D08469  Rasagiline (USAN/INN)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Monoamine Oxidase B (MAO-B) Inhibitors
   Rasagiline
    D08469  Rasagiline (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAOB
     D08469  Rasagiline (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08469
BRITE hierarchy
Other DBs
CAS: 136236-51-6
PubChem: 96025155
ChEBI: 63620
ChEMBL: CHEMBL887
DrugBank: DB01367
PDB-CCD: RAU[PDBj]
LigandBox: D08469
NIKKAJI: J573.894F
LinkDB All DBs
KCF data Show

ATOM        13
            1   C8y C    22.8900  -17.7100
            2   C8y C    22.8900  -16.3100
            3   C8x C    21.7000  -15.6100
            4   C8x C    20.5100  -16.3100
            5   C8x C    20.5100  -17.7100
            6   C8x C    21.7000  -18.4100
            7   C1y C    24.2200  -18.1300
            8   C1x C    25.0600  -17.0100
            9   C1x C    24.2200  -15.8200
            10  N1b N    24.2200  -19.5300
            11  C1b C    25.4800  -20.2300
            12  C3b C    26.6700  -19.5300
            13  C3a C    27.8600  -18.8300
BOND        14
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    2   9 1
            11    7  10 1 #Up
            12   10  11 1
            13   11  12 1
            14   12  13 3

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