| Entry |
|
|---|
| Name |
Sotalol (INN);
Darob mite (TN) |
|---|
| Formula |
C12H20N2O3S
|
|---|
| Exact mass |
272.1195
|
|---|
| Mol weight |
272.37
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01648 Class III antiarrhythmic agent
|
|---|
| Remark |
| Product (DG00307): | D01026<JP/US> |
|
|---|
| Efficacy |
Antiarrhythmic, beta-Adrenergic receptor antagonist, Potassium channel blocker |
|---|
| Comment |
Class III antiarrhythmic agent
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07232 | Potassium channel blocking and opening drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA07 Sotalol
D08525 Sotalol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00307 Sotalol
D08525 Sotalol
DG01653 Antiarrhythmics
DG01648 Class III antiarrhythmic agent
DG00307 Sotalol
D08525 Sotalol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D08525 Sotalol (INN)
ADRB2
D08525 Sotalol (INN)
Ion channels
Voltage-gated ion channels
Potassium channels
KCNH2
D08525 Sotalol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00307 Sotalol
DG01653 Antiarrhythmics
DG01648 Class III antiarrhythmic agent
DG00307 Sotalol
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 18
1 C8y C 24.1500 -17.9900
2 C1c C 25.3400 -18.6900
3 C8x C 24.1500 -16.5200
4 C8x C 22.8900 -18.6900
5 C1b C 26.5300 -17.9900
6 O1a O 25.3400 -20.0900
7 C8x C 22.8900 -15.8200
8 C8x C 21.7700 -17.9900
9 N1b N 27.7900 -18.6900
10 C8y C 21.7700 -16.5200
11 C1c C 28.9800 -17.9900
12 N1b N 20.5800 -15.8200
13 C1a C 30.1700 -18.6900
14 C1a C 28.9800 -16.5900
15 S4a S 19.3200 -16.5200
16 C1a C 18.1300 -15.8200
17 O3c O 20.5800 -17.2900
18 O3c O 18.2700 -17.2900
BOND 18
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 1
8 5 9 1
9 7 10 1
10 9 11 1
11 10 12 1
12 11 13 1
13 11 14 1
14 12 15 1
15 15 16 1
16 15 17 2
17 15 18 2
18 8 10 2
|
|---|
