KEGG   DRUG: dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
Entry
D08695            Mixture   Drug                                   
Name
dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea;
Coughcode N (TN)
Component
dl-Methylephedrine hydrochloride [DR:D02109], Dihydrocodeine phosphate [DR:D01481], Diprophylline [DR:D00691], Diphenhydramine salicylate [DR:D02419], Acetaminophen [DR:D00217], Bromovalerylurea [DR:D01391]
Class
Respiratory system agent
 DG03282  Ephedrine-containing preparation
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
Therapeutic category: 2229
ATC code: N02AA58
Product: D08695<JP>
Efficacy
Analgesic, Antipyretic, Antitussive
Comment
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA58 Dihydrocodeine, combinations
      D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   222  Antitussives
    2229  Others
     D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
Drug groups [BR:br08330]
 Respiratory system agent
  DG03282  Ephedrine-containing preparation
   D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
   DG03190  UGT2B7 substrate
    D08695  dl-Methylephedrine hydrochloride, dihydrocodeine phosphate, diprophylline, diphenhydramine salicylate, acetaminophen and bromovalerylurea
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08695
Other DBs
PubChem: 96025378
LinkDB

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