KEGG   DRUG: Levamlodipine malate
Entry
D08941                      Drug                                   
Name
Levamlodipine malate (USAN)
Formula
C20H25ClN2O5. C4H6O5
Exact mass
542.1667
Mol weight
542.9633
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01928  Dihydropyridine calcium channel blocker
Remark
ATC code: C08CA17
Chemical structure group: DG03091
Product (DG03091): D11723<US>
Efficacy
Antihypertensive, Vasodilator
Comment
Dihydropyridine derivative
See Amlodipine [DR:D07450]
Treatment of Hypertension, Chronic stable angina, Vasospastic angina
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA17 Levamlodipine
      D08941  Levamlodipine malate (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01928  Dihydropyridine calcium channel blocker
    D08941  Levamlodipine malate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D08941  Levamlodipine malate (USAN)
Other DBs
CAS: 736178-83-9
PubChem: 96025624
LigandBox: D08941
LinkDB
KCF data

ATOM        37
            1   C2y C    14.3290  -12.1664
            2   C2y C    14.3290  -13.5649
            3   C1y C    15.5401  -14.2641
            4   C2y C    16.7513  -13.5649
            5   C2y C    16.7513  -12.1664
            6   N1x N    15.5401  -11.4671
            7   C1b C    17.9874  -11.4671
            8   O2a O    19.1986  -12.1664
            9   C1b C    20.4097  -11.4671
            10  C1b C    21.6208  -12.1664
            11  N1a N    22.8320  -11.4671
            12  C7a C    17.9874  -14.2641
            13  O7a O    19.1986  -13.5649
            14  C1b C    20.4097  -14.2641
            15  C1a C    21.6208  -13.5649
            16  C1a C    13.1179  -11.4671
            17  C7a C    13.1179  -14.2641
            18  O7a O    11.9237  -13.5744
            19  C8y C    15.5401  -15.6624
            20  C8x C    14.3122  -16.3715
            21  C8x C    14.3124  -17.7700
            22  C8x C    15.5236  -18.4691
            23  C8x C    16.7515  -17.7600
            24  C8y C    16.7513  -16.3615
            25  O6a O    13.1178  -15.6624
            26  C1a C    10.7376  -14.2592
            27  O6a O    17.9936  -15.4000
            28  X   Cl   18.0113  -16.3615
            29  O6a O    27.6146  -13.8446
            30  C6a C    28.8257  -14.5438
            31  C1c C    30.0367  -13.8446
            32  C1b C    31.2478  -14.5438
            33  C6a C    32.4589  -13.8446
            34  O6a O    33.6701  -14.5438
            35  O6a O    28.8257  -15.9421
            36  O6a O    32.4589  -12.4462
            37  O1a O    30.0367  -12.4463
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    4  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16    1  16 1
            17    2  17 1
            18   17  18 1
            19    3  19 1 #Up
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   19  24 1
            26   17  25 2
            27   18  26 1
            28   12  27 2
            29   24  28 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   33  34 1
            35   30  35 2
            36   33  36 2
            37   31  37 1 #Up

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