KEGG   DRUG: FostamatinibHelp
Entry
D09347                      Drug                                   

Name
Fostamatinib (USAN)
Product
Formula
C23H26FN6O9P
Exact mass
580.1483
Mol weight
580.4595
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
Remark
Chemical structure group: DG01419
Product (DG01419): D09347<US>
Efficacy
Antineoplastic, Immunomodulator, Tyrosin kinase inhibitor
Comment
Treatment of rheumatoid arthritis, immune thrombocytopenic purpura, and B-cell lymphoma
Target
SYK [HSA:6850] [KO:K05855]
  Pathway
hsa04064  NF-kappa B signaling pathway
hsa04662  B cell receptor signaling pathway
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Non-receptor tyrosine kinases
   SYK family
    SYK
     D09347  Fostamatinib (USAN) <US>
BRITE hierarchy
Other DBs
CAS: 901119-35-5
PubChem: 96026027
ChEMBL: CHEMBL2103830
PDB-CCD: 2RC[PDBj]
LigandBox: D09347
LinkDB All DBs
KCF data Show

ATOM        40
            1   N1b N    19.2868  -25.2551
            2   C8y C    19.2868  -23.8526
            3   N5x N    18.0947  -23.1513
            4   C8x C    18.0947  -21.7488
            5   C8y C    19.2868  -21.0475
            6   C8y C    20.5491  -21.7488
            7   N5x N    20.5491  -23.1513
            8   X   F    19.2868  -19.6450
            9   N1b N    21.7413  -21.0475
            10  C8y C    22.9334  -21.7488
            11  N5x N    24.1256  -21.0475
            12  C8y C    25.3879  -21.7488
            13  C8y C    25.3879  -23.1513
            14  C8x C    24.1957  -23.8526
            15  C8x C    22.9334  -23.1513
            16  N1y N    26.5800  -21.0475
            17  C5x C    27.7722  -21.7488
            18  C1z C    27.7722  -23.1513
            19  O2x O    26.5800  -23.8526
            20  C1a C    28.9644  -23.8526
            21  C1a C    28.9644  -22.4500
            22  O5x O    28.9644  -21.0475
            23  C1b C    26.5800  -19.6450
            24  O2b O    27.7722  -18.9437
            25  P1b P    27.7722  -17.5412
            26  C8y C    20.5014  -25.9564
            27  C8x C    20.5014  -27.3587
            28  C8y C    21.7161  -28.0600
            29  C8y C    22.9307  -27.3587
            30  C8y C    22.9307  -25.9564
            31  C8x C    21.7161  -25.2551
            32  O2a O    24.1474  -28.0612
            33  O2a O    24.1474  -25.2539
            34  O2a O    21.7161  -29.4625
            35  O1c O    29.1747  -17.5412
            36  O1c O    26.3697  -17.5412
            37  O1c O    27.7722  -16.1386
            38  C1a C    25.3688  -25.9589
            39  C1a C    25.3580  -27.3623
            40  C1a C    22.9196  -30.1575
BOND        43
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     6   7 2
            7     2   7 1
            8     5   8 1
            9     6   9 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17   12  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   13  19 1
            22   18  20 1
            23   18  21 1
            24   17  22 2
            25   16  23 1
            26   23  24 1
            27   24  25 1
            28    1  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   26  31 1
            35   29  32 1
            36   30  33 1
            37   28  34 1
            38   25  35 1
            39   25  36 1
            40   25  37 2
            41   33  38 1
            42   32  39 1
            43   34  40 1

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