KEGG   DRUG: Eslicarbazepine acetateHelp
Entry
D09612                      Drug                                   

Name
Eslicarbazepine acetate (USAN);
Zebinix (TN);
Aptiom (TN)
Product
Formula
C17H16N2O3
Exact mass
296.1161
Mol weight
296.3205
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02034  Carboxamide antiepileptics
Enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Enzyme inducer
 DG02853  CYP3A inducer
  DG01635  CYP3A4 inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: N03AF04
Chemical structure group: DG00848
Product (DG00848): D09612<US>
Efficacy
Antiepileptic
Comment
Carboxamide derivative
Adjunctive therapy for adults with partial-onset seizures
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF04 Eslicarbazepine
      D09612  Eslicarbazepine acetate (USAN) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Eslicarbazepine
    D09612  Eslicarbazepine acetate (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN2A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN3A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN4A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN5A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN8A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN9A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN10A
     D09612  Eslicarbazepine acetate (USAN) <US>
    SCN11A
     D09612  Eslicarbazepine acetate (USAN) <US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D09612
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09612
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09612
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09612
BRITE hierarchy
Other DBs
CAS: 236395-14-5
PubChem: 124490352
ChEMBL: CHEMBL87992
LigandBox: D09612
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    22.4000  -25.4100
            2   N1y N    23.6600  -24.7800
            3   C8y C    24.9200  -25.4100
            4   C8y C    25.2000  -26.7400
            5   C8y C    22.1200  -26.8100
            6   C1x C    24.3600  -27.8600
            7   C1y C    22.9600  -27.8600
            8   C8x C    21.3500  -24.4300
            9   C8x C    20.0200  -24.9200
            10  C8x C    19.7400  -26.2500
            11  C8x C    20.7900  -27.2300
            12  C8x C    26.6000  -27.0900
            13  C8x C    27.5800  -26.1100
            14  C8x C    27.2300  -24.7800
            15  C8x C    25.8300  -24.3600
            16  C5a C    23.6600  -23.3800
            17  O5a O    22.4700  -22.6800
            18  N1a N    24.8500  -22.6800
            19  O7a O    22.3300  -29.1200
            20  C7a C    20.9300  -29.1200
            21  O6a O    20.2300  -27.9076
            22  C1a C    20.2300  -30.3324
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1
            21    7  19 1 #Down
            22   19  20 1
            23   20  21 2
            24   20  22 1

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