KEGG   DRUG: Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
Entry
D10571            Mixture   Drug                                   
Name
Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine;
Complera (TN);
Eviplera (TN)
Product
COMPLERA (Gilead Sciences)
Component
Rilpivirine hydrochloride [DR:D09958], Tenofovir disoproxil fumarate [DR:D01982], Emtricitabine [DR:D01199]
Class
Antiviral
 DG03107  Anti-HIV agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
ATC code: J05AR08
Product: D10571<US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Comment
Rilpivirine is primarily metabolized by CYP3A.
Target
HIV-1 reverse transcriptase [KO:K24802]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko03250  Viral life cycle - HIV-1
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR08 Emtricitabine, tenofovir disoproxil and rilpivirine
      D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine <US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Combinations
   Emtricitabine/ Rilpivirine/ Tenofovir Disoproxil Fumarate
    D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
Drug groups [BR:br08330]
 Antiviral
  DG03107  Anti-HIV agent
   D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D10571  Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10571
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10571
Other DBs
PubChem: 254741533
LinkDB

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