KEGG   DRUG: Emtricitabine
Entry
D01199                      Drug                                   
Name
Emtricitabine (JAN/USAN/INN);
Emtriva (TN)
  Abbr
FTC
Product
  Generic
Formula
C8H10FN3O3S
Exact mass
247.0427
Mol weight
247.2467
Structure
Simcomp
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG01440  Arabinofuranosyl type antiviral
 DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
 DG02860  SLC22A8 substrate
Remark
Same as: C12599
Therapeutic category: 6250
ATC code: J05AF09
Product: D01199<JP/US>
Product (mixture): D02297<JP/US> D10571<US> D10755<JP/US> D10756<JP/US> D10835<JP/US> D10836<JP/US> D10851<US> D11039<JP/US> D11382<JP/US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Target
HIV-1 reverse transcriptase [KO:K24802]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko03250  Viral life cycle - HIV-1
Metabolism
Transporter: SLC22A8 [HSA:9376]
Interaction
Structure map
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF09 Emtricitabine
      D01199  Emtricitabine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
   Emtricitabine
    D01199  Emtricitabine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D01199  Emtricitabine (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   D01199  Emtricitabine
  DG01440  Arabinofuranosyl type antiviral
   D01199  Emtricitabine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D01199  Emtricitabine
 Transporter substrate
  DG02860  SLC22A8 substrate
   D01199  Emtricitabine
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D01199  Emtricitabine
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D01199  Emtricitabine (JAN/USAN/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D01199  Emtricitabine (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01199
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01199
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01199
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01199
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D01199
Other DBs
CAS: 143491-57-0
PubChem: 7848262
ChEBI: 31536
PDB-CCD: ETV[PDBj]
LigandBox: D01199
LinkDB
KCF data

ATOM        16
            1   N4y N    25.0103  -17.6390
            2   C1y C    23.6350  -18.1111
            3   C1y C    21.3970  -18.1111
            4   C1b C    20.1381  -17.4117
            5   O1a O    18.9492  -18.1111
            6   S2x S    21.8166  -19.4399
            7   O2x O    22.5160  -17.2718
            8   C1x C    23.2154  -19.4399
            9   C8x C    25.0206  -16.2402
            10  C8y C    26.2146  -15.5496
            11  C8y C    27.4684  -16.2582
            12  N5x N    27.4581  -17.6570
            13  C8y C    26.2641  -18.3476
            14  N1a N    28.6624  -15.5676
            15  X   F    26.1549  -14.1509
            16  O5x O    26.2538  -19.7463
BOND        17
            1     8   6 1
            2     4   5 1
            3     2   1 1 #Down
            4     3   4 1 #Down
            5     6   3 1
            6     1   9 1
            7     9  10 2
            8    10  11 1
            9    11  12 2
            10   12  13 1
            11   13   1 1
            12    3   7 1
            13   11  14 1
            14    7   2 1
            15   10  15 1
            16    2   8 1
            17   13  16 2

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