KEGG   DRUG: EmtricitabineHelp
Entry
D01199                      Drug                                   

Name
Emtricitabine (JAN/USAN/INN);
Emtriva (TN)
Product
Formula
C8H10FN3O3S
Exact mass
247.0427
Mol weight
247.2467
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG01440  Arabinofuranosyl type antiviral
 DG01656  HIV reverse transcriptase inhibitor
Unclassified
 DG02867  ABCC2 (MRP2) inhibitor
Remark
Same as: C12599
Therapeutic category: 6250
ATC code: J05AF09
Product: D01199<JP/US>
Product (mixture): D02297<JP/US> D10571<JP/US> D10756<JP/US> D10755<JP/US> D10836<US> D10835<JP/US> D10851<US> D11039<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Target
RNA-directed DNA polymerase
Interaction
Transporter inhibition: ABCC2 [HSA:1244], ABCC3 [HSA:8714]
Drug interaction
Structure map
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF09 Emtricitabine
      D01199  Emtricitabine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Emtricitabine
    D01199  Emtricitabine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D01199  Emtricitabine (JAN/USAN/INN)
Antiinfectives [br08350.html]
 Antivirals
  D01199
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01199
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01199
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01199
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01199
BRITE hierarchy
Other DBs
CAS: 143491-57-0
PubChem: 7848262
ChEBI: 31536
ChEMBL: CHEMBL885
DrugBank: DB00879
PDB-CCD: ETV[PDBj]
LigandBox: D01199
LinkDB All DBs
KCF data Show

ATOM        16
            1   N4y N    25.0103  -17.6390
            2   C1y C    23.6350  -18.1111
            3   C1y C    21.3970  -18.1111
            4   C1b C    20.1381  -17.4117
            5   O1a O    18.9492  -18.1111
            6   S2x S    21.8166  -19.4399
            7   O2x O    22.5160  -17.2718
            8   C1x C    23.2154  -19.4399
            9   C8x C    25.0206  -16.2402
            10  C8y C    26.2146  -15.5496
            11  C8y C    27.4684  -16.2582
            12  N5x N    27.4581  -17.6570
            13  C8y C    26.2641  -18.3476
            14  N1a N    28.6624  -15.5676
            15  X   F    26.1549  -14.1509
            16  O5x O    26.2538  -19.7463
BOND        17
            1     8   6 1
            2     4   5 1
            3     2   1 1 #Down
            4     3   4 1 #Down
            5     6   3 1
            6     1   9 1
            7     9  10 2
            8    10  11 1
            9    11  12 2
            10   12  13 1
            11   13   1 1
            12    3   7 1
            13   11  14 1
            14    7   2 1
            15   10  15 1
            16    2   8 1
            17   13  16 2

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