| Entry |
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| Name |
Etelcalcetide (USAN/INN);
Velcalcetide |
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| Formula |
C38H73N21O10S2
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| Exact mass |
1047.5291
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| Mol weight |
1048.26
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| Structure |
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| Simcomp |
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| Remark |
| Product (DG01856): | D10677<JP/US> |
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| Efficacy |
Antihyperparathyroidism, Calcium-sensing receptor agonist |
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| Comment |
Treatment of secondary hyperparathyroidism associated with chronic kidney disease
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| Target |
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| Pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04928 | Parathyroid hormone synthesis, secretion and action |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H05 CALCIUM HOMEOSTASIS
H05B ANTI-PARATHYROID AGENTS
H05BX Other anti-parathyroid agents
H05BX04 Etelcalcetide
D10676 Etelcalcetide (USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Metabotropic glutamate receptor family
Calcium-sensing
CASR
D10676 Etelcalcetide (USAN/INN)
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 71
1 C1c C 7.4734 -17.1598
2 C6a C 8.6860 -17.8597
3 O6a O 9.9151 -17.1499
4 N1a N 6.2610 -17.8598
5 O6a O 8.6860 -19.2597
6 C5a C 7.4900 -11.5500
7 C1c C 9.9149 -11.5500
8 N1b N 8.7024 -10.8500
9 C5a C 11.1273 -10.8500
10 C5a C 13.5542 -9.4512
11 C1c C 12.3397 -8.7500
12 N1b N 11.1273 -9.4500
13 C5a C 15.9791 -10.8512
14 C1c C 15.9791 -9.4512
15 N1b N 14.7666 -8.7512
16 N1b N 17.1915 -11.5512
17 C1c C 17.1915 -12.9497
18 C5a C 18.4040 -13.6497
19 N1b N 19.6164 -12.9497
20 C1c C 20.8288 -13.6497
21 C5a C 20.8288 -15.0497
22 C1c C 22.0413 -17.1497
23 N1b N 22.0412 -15.7497
24 C5a C 23.2537 -17.8497
25 N1b N 23.2537 -19.2497
26 C1c C 24.4662 -19.9497
27 C5a C 24.4662 -21.3497
28 O5a O 25.6786 -22.0496
29 C1a C 6.2776 -10.8500
30 O5a O 7.4900 -12.9500
31 O5a O 12.3397 -11.5500
32 O5a O 13.5542 -10.8512
33 O5a O 14.7667 -11.5512
34 O5a O 18.4040 -15.0497
35 O5a O 19.6164 -15.7497
36 O5a O 24.4661 -17.1497
37 S3a S 8.7024 -13.6500
38 C1b C 9.9149 -12.9500
39 S3a S 8.7024 -15.0500
40 C1b C 7.4733 -15.7598
41 C1b C 15.9791 -13.6497
42 C1b C 15.9791 -15.0497
43 C1b C 17.1916 -15.7497
44 N1b N 17.1916 -17.1497
45 C2c C 18.4041 -17.8497
46 N1a N 19.6165 -17.1497
47 N2a N 18.4041 -19.2497
48 C1a C 20.8289 -17.8497
49 C1a C 12.3397 -7.3500
50 C1b C 17.1915 -8.7512
51 C1b C 17.1915 -7.3512
52 C1b C 18.4039 -6.6512
53 N1b N 18.4039 -5.2512
54 C2c C 19.6164 -4.5512
55 N1a N 20.8288 -5.2512
56 C1b C 22.0413 -12.9497
57 C1b C 22.0413 -11.5511
58 C1b C 23.2537 -10.8511
59 N1b N 23.2537 -9.4511
60 C2c C 22.0413 -8.7511
61 N2a N 20.8289 -9.4511
62 C1b C 25.6786 -19.2497
63 N2a N 19.6164 -3.1512
64 N1a N 22.0413 -7.3511
65 C1b C 26.8910 -19.9497
66 C1b C 28.1035 -19.2497
67 N1b N 29.3159 -19.9497
68 C2c C 30.5283 -19.2497
69 N1a N 30.5283 -17.8497
70 N2a N 31.7408 -19.9497
71 N1a N 23.2538 -22.0497
BOND 70
1 1 2 1
2 2 3 1
3 1 4 1
4 2 5 2
5 7 8 1
6 6 8 1
7 7 9 1
8 10 11 1
9 11 12 1
10 9 12 1
11 13 14 1
12 14 15 1
13 10 15 1
14 13 16 1
15 16 17 1
16 17 18 1
17 18 19 1
18 19 20 1
19 20 21 1
20 22 23 1
21 21 23 1
22 22 24 1
23 24 25 1
24 25 26 1
25 26 27 1
26 27 28 2
27 6 29 1
28 6 30 2
29 9 31 2
30 10 32 2
31 13 33 2
32 18 34 2
33 21 35 2
34 24 36 2
35 37 38 1
36 37 39 1
37 39 40 1
38 7 38 1 #Up
39 1 40 1 #Up
40 41 42 1
41 42 43 1
42 43 44 1
43 44 45 1
44 45 46 1
45 45 47 2
46 17 41 1 #Up
47 22 48 1 #Up
48 11 49 1 #Down
49 50 51 1
50 51 52 1
51 52 53 1
52 53 54 1
53 54 55 1
54 14 50 1 #Down
55 56 57 1
56 57 58 1
57 58 59 1
58 59 60 1
59 60 61 2
60 20 56 1 #Down
61 26 62 1 #Down
62 54 63 2
63 60 64 1
64 62 65 1
65 65 66 1
66 66 67 1
67 67 68 1
68 68 69 1
69 68 70 2
70 27 71 1
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