KEGG   DRUG: Ombitasvir, paritaprevir and ritonavirHelp
Entry
D10745            Mixture   Drug                                   

Name
Ombitasvir, paritaprevir and ritonavir;
Technivie (TN)
Product
Component
(Ombitasvir hydrate [DR:D10598] | Ombitasvir [DR:D10576]), (Paritaprevir hydrate [DR:D10597] | Paritaprevir [DR:D10580]), Ritonavir [DR:D00427]
Remark
Therapeutic category: 6250
ATC code: J05AP53
Product: D10745<US>
Efficacy
Antiviral
  Disease
Chronic hepatitis C virus infection [DS:H00413]
Comment
Paritaprevir is an inhibitor and a substrate of P-gp, BCRP and OATP1B1/1B3.
Ombitasvir is metabolized by P-gp.
Ritonavir is an inhibitor and a substrate of P-gp; it is also an inhibitor of CYP3A4 and BCRP.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Transporter: ABCB1 [HSA:5243], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCG2 [HSA:9429]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCG2 [HSA:9429]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AP Antivirals for treatment of HCV infections
     J05AP53 Ombitasvir, paritaprevir and ritonavir
      D10745  Ombitasvir, paritaprevir and ritonavir <US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis C (HCV) Agents Direct Acting Agents
   Ombitasvir/ Paritaprevir/ Ritonavir
    D10745  Ombitasvir, paritaprevir and ritonavir
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10745  Ombitasvir, paritaprevir and ritonavir
Antiinfectives [br08350.html]
 Antivirals
  D10745
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10745
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10745
BRITE hierarchy
Other DBs
PubChem: 254741706
ChEBI: 90919
LinkDB All DBs

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