KEGG   DRUG: Emtricitabine, rilpivirine and tenofovir alafenamide
Entry
D10836            Mixture   Drug                                   
Name
Emtricitabine, rilpivirine and tenofovir alafenamide;
Odefsey (TN)
Product
Component
Emtricitabine [DR:D01199], (Rilpivirine hydrochloride [DR:D09958] | Rilpivirine [DR:D09720]), (Tenofovir alafenamide fumarate [DR:D10605] | Tenofovir alafenamide [DR:D10428])
Class
Antiviral
 DG03107  Anti-HIV agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
 DG03001  CTSA substrate
Remark
Therapeutic category: 6250
ATC code: J05AR19
Product: D10836<JP/US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Comment
Rilpivirine is primarily metabolized by CYP3A.
Tenofovir alafenamide is a substrate of cathepsin A, CYP3A and P-gp.
Target
HIV-1 reverse transcriptase [KO:K24802]
Metabolism
Enzyme: CTSA [HSA:5476], CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR19 Emtricitabine, tenofoviralafenamide and rilpivirine
      D10836  Emtricitabine, rilpivirine and tenofovir alafenamide <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Combinations
   Emtricitabine/ Rilpivirine/ Tenofovir Alafenamide Fumarate
    D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
Drug groups [BR:br08330]
 Antiviral
  DG03107  Anti-HIV agent
   D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
 Transporter substrate
  DG01665  ABCB1 substrate
   D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
  DG03001  CTSA substrate
   D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D10836  Emtricitabine, rilpivirine and tenofovir alafenamide
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D10836  Emtricitabine, rilpivirine and tenofovir alafenamide <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10836
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10836
 Drug transporters
  D10836
Other DBs
PubChem: 319902636
LinkDB

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