| Entry |
|
|---|
| Name |
Bexagliflozin (USAN);
Brenzavvy (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C24H29ClO7
|
|---|
| Exact mass |
464.1602
|
|---|
| Mol weight |
464.93
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antidiabetic, SGLT-2 inhibitor |
|---|
| Disease |
Type 2 diabetes mellitus [DS: H00409] |
|---|
| Target |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
A10BK08 Bexagliflozin
D10865 Bexagliflozin (USAN) <US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
Antidiabetic Agents
Sodium-Glucose Co-Transporter 2 (SGLT2) Inhbitor
Bexagliflozin
D10865 Bexagliflozin (USAN)
Kidney Agents
Sodium-Glucose Co-transporter 2 (SGLT2) Inhibitors
Bexagliflozin
D10865 Bexagliflozin (USAN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
D10865 Bexagliflozin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
D10865 Bexagliflozin
DG02924 UGT substrate
DG03188 UGT1A9 substrate
D10865 Bexagliflozin
Drug classes [BR:br08332]
Antidiabetic agent
DG01794 SGLT2 inhibitor
D10865 Bexagliflozin
DG02044 Hypoglycemic agent
D10865 Bexagliflozin
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC5
SLC5A2 (SGLT2)
D10865 Bexagliflozin (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10865
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10865
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10865
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
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| KCF data |
ATOM 32
1 C1y C 6.8600 -16.0300
2 O2x O 6.8600 -14.6300
3 C1y C 5.6700 -13.9300
4 C1y C 4.4100 -14.6300
5 C1y C 4.4100 -16.0300
6 C1y C 5.6700 -16.7300
7 O1a O 5.6700 -18.1300
8 O1a O 3.2200 -13.9300
9 O1a O 3.2200 -16.7300
10 C1b C 5.6700 -12.5300
11 C8y C 8.0500 -16.7300
12 C8x C 8.0500 -18.1300
13 C8x C 9.3100 -18.8300
14 C8y C 10.5000 -18.1300
15 C8y C 10.5000 -16.7300
16 C8x C 9.3100 -16.0300
17 X Cl 11.6900 -18.8300
18 C1b C 11.6900 -16.0300
19 C8y C 12.8800 -16.7300
20 C8x C 12.8800 -18.1300
21 C8x C 14.1400 -18.8300
22 C8y C 15.3300 -18.1300
23 C8x C 15.3300 -16.7300
24 C8x C 14.1400 -16.0300
25 O2a O 16.5200 -18.8300
26 C1b C 17.7100 -18.1300
27 C1b C 18.9000 -18.8300
28 O2a O 20.0900 -18.1300
29 C1y C 21.2800 -18.8300
30 C1x C 22.6800 -18.8300
31 C1x C 21.9800 -20.0200
32 O1a O 6.8600 -11.8300
BOND 35
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 6 7 1 #Down
8 4 8 1 #Down
9 5 9 1 #Up
10 3 10 1 #Up
11 1 11 1 #Up
12 11 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 11 16 1
18 14 17 1
19 15 18 1
20 18 19 1
21 19 20 2
22 20 21 1
23 21 22 2
24 22 23 1
25 23 24 2
26 19 24 1
27 22 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 28 29 1
32 30 29 1
33 31 30 1
34 29 31 1
35 10 32 1
|
|---|
