KEGG   DRUG: TucatinibHelp
Entry
D11141                      Drug                                   

Name
Tucatinib (USAN/INN);
Tukysa (TN)
Product
Formula
C26H24N8O2
Exact mass
480.2022
Mol weight
480.5212
Structure
Mol fileKCF fileDB search
Remark
Product: D11141<US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Breast cancer (HER2 positive) [DS:H00031]
Target
ERBB2 (HER2, CD340) [HSA:2064] [KO:K05083]
ERBB3 (HER3) [HSA:2065] [KO:K05084]
  Network
N10009  Tyrosine kinase inhibitor to HER2 overexpression/amplification
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05224  Breast cancer
Metabolism
Enzyme: CYP2C8 [HSA:1558]; CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    ERBB2 (HER2, CD340)
     D11141  Tucatinib (USAN/INN) <US>
    ERBB3 (HER3)
     D11141  Tucatinib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11141
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11141
BRITE hierarchy
Other DBs
CAS: 937263-43-9
PubChem: 376219065
ChEMBL: CHEMBL3989868
LinkDB All DBs
KCF data Show

ATOM        36
            1   C8y C    24.3600  -13.7900
            2   C8y C    24.3600  -15.1900
            3   C8y C    23.1700  -15.8900
            4   N5x N    21.9100  -15.1900
            5   C8x C    21.9100  -13.7900
            6   N5x N    23.1700  -13.0900
            7   C8x C    25.5500  -13.0900
            8   C8x C    26.8100  -13.7900
            9   C8y C    26.8100  -15.1900
            10  C8x C    25.5500  -15.8900
            11  N1b N    28.0000  -15.8900
            12  C2y C    29.1900  -15.1900
            13  O2x O    29.1900  -13.7900
            14  C1x C    30.5200  -13.3000
            15  C1z C    31.3600  -14.4200
            16  N2x N    30.5900  -15.6100
            17  N1b N    23.1700  -17.2900
            18  C1a C    32.0600  -13.2300
            19  C1a C    32.3400  -15.4000
            20  C8y C    24.3853  -17.9851
            21  C8x C    24.3911  -19.3897
            22  C8x C    25.6064  -20.0847
            23  C8y C    26.8159  -19.3797
            24  C8y C    26.8101  -17.9751
            25  C8x C    25.5948  -17.2801
            26  C1a C    28.0131  -17.2740
            27  O2a O    28.0312  -20.0746
            28  C8y C    27.9674  -21.4906
            29  C8x C    26.7728  -22.1638
            30  C8x C    26.7582  -23.5637
            31  N4y N    27.9632  -24.2763
            32  C8y C    29.1578  -23.6032
            33  C8x C    29.1724  -22.2033
            34  N5x N    28.2343  -25.6205
            35  C8x C    29.5964  -25.7781
            36  N5x N    30.1671  -24.5313
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   12  16 2
            19    3  17 1
            20   15  18 1
            21   15  19 1
            22   17  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   20  25 1
            29   24  26 1
            30   23  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 2
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   28  33 2
            38   31  34 1
            39   34  35 2
            40   35  36 1
            41   32  36 2

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