KEGG   DRUG: Difamilast
Entry
D11314                      Drug                                   
Name
Difamilast (JAN/USAN);
Moizerto (TN)
Formula
C23H24F2N2O5
Exact mass
446.1653
Mol weight
446.44
Structure
Class
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 2699
Product: D11314<JP>
Efficacy
Anti-inflammatory, Phosphodiesterase IV inhibitor
Comment
Treatment of atopic dermatitis
Target
PDE4 [HSA:5141 5142 5143 5144] [KO:K13293]
  Pathway
hsa00230  Purine metabolism
hsa04024  cAMP signaling pathway
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   269  Miscellaneous
    2699  Others
     D11314  Difamilast (JAN/USAN)
Drug groups [BR:br08330]
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D11314  Difamilast
Drug classes [BR:br08332]
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D11314  Difamilast
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    PDE4
     D11314  Difamilast (JAN/USAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11314
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11314
Other DBs
CAS: 937782-05-3
PubChem: 384585292
LinkDB
KCF data

ATOM        32
            1   C8y C    11.9700  -16.1000
            2   C8y C    11.9700  -17.5000
            3   C8x C    13.1600  -18.2000
            4   C8y C    14.4200  -17.5000
            5   C8x C    14.4200  -16.1000
            6   C8x C    13.1600  -15.4000
            7   O2a O    10.7800  -15.4000
            8   C1c C     9.5900  -16.1000
            9   X   F     8.4000  -15.4000
            10  X   F     9.5900  -17.5000
            11  O2a O    10.7800  -18.2000
            12  C1c C    10.7800  -19.6000
            13  C1a C     9.5900  -20.3000
            14  C1a C    11.9700  -20.3000
            15  C8y C    15.6100  -18.2000
            16  O2x O    16.1000  -19.5300
            17  C8x C    17.4300  -19.5300
            18  C8y C    17.8500  -18.2000
            19  N5x N    16.7300  -17.3600
            20  C1b C    19.0400  -17.5000
            21  N1b N    20.2300  -18.2000
            22  C5a C    21.4200  -17.5000
            23  C8y C    22.6100  -18.2000
            24  O5a O    21.4200  -16.1000
            25  C8x C    22.6100  -19.6000
            26  C8x C    23.8700  -20.3000
            27  C8x C    25.0600  -19.6000
            28  C8x C    25.0600  -18.2000
            29  C8y C    23.8700  -17.5000
            30  O2a O    23.8700  -16.1000
            31  C1b C    25.0600  -15.4000
            32  C1a C    26.2500  -16.1000
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 1
            11    2  11 1
            12   11  12 1
            13   12  13 1
            14   12  14 1
            15    4  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   15  19 2
            21   20  21 1
            22   20  18 1
            23   21  22 1
            24   22  23 1
            25   22  24 2
            26   23  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   23  29 1
            32   29  30 1
            33   30  31 1
            34   31  32 1

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