KEGG   DRUG: Solriamfetol hydrochloride
Entry
D11328                      Drug                                   
Name
Solriamfetol hydrochloride (USAN);
Sunosi (TN)
Product
SUNOSI (Axsome Therapeutics)
Formula
C10H14N2O2. HCl
Exact mass
230.0822
Mol weight
230.6913
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
Remark
ATC code: N06BA14
Chemical structure group: DG02989
Product (DG02989): D11328<US>
Efficacy
Wake-promoting agent, Noradrenalin and dopamine reuptake inhibitor
  Disease
Narcolepsy [DS:H01293]
Comment
Wake-promoting agent for the treatment of excessive sleepiness associated with narcolepsy or obstructive sleep apnea
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA14 Solriamfetol
      D11328  Solriamfetol hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Wakefulness Promoting Agents
   Solriamfetol
    D11328  Solriamfetol hydrochloride (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
   DG02989  Sorliamfetol
    D11328  Solriamfetol hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D11328  Solriamfetol hydrochloride (USAN) <US>
    SLC6A3 (DAT1)
     D11328  Solriamfetol hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11328
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11328
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11328
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03059  Noradrenalin and dopamine reuptake inhibitor (NDRI)
   DG02989  Sorliamfetol
Other DBs
CAS: 178429-65-7
PubChem: 384585306
LinkDB
KCF data

ATOM        15
            1   C8x C    13.7981  -16.1795
            2   C8x C    13.7981  -17.5803
            3   C8x C    15.0589  -18.2807
            4   C8x C    16.2496  -17.5803
            5   C8y C    16.2496  -16.1795
            6   C8x C    15.0589  -15.4791
            7   C1b C    17.5103  -15.4791
            8   C1c C    18.7010  -16.1795
            9   C1b C    19.8917  -15.4791
            10  O7a O    21.0824  -16.1795
            11  C7a C    22.2731  -15.4791
            12  N1a N    23.4638  -16.1795
            13  O6a O    22.2731  -14.0783
            14  N1a N    18.7010  -17.5803
            15  X   Cl   26.6000  -18.2000
BOND        14
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   11  13 2
            14    8  14 1 #Down

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