KEGG   DRUG: Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
Entry
D11382            Mixture   Drug                                   
Name
Darunavir, cobicistat, emtricitabine and tenofovir alafenamide;
Symtuza (TN)
Product
Component
(Darunavir [DR:D03656] | Darunavir ethanolate [DR:D06478]), Cobicistat [DR:D09881], Emtricitabine [DR:D01199], (Tenofovir alafenamide [DR:D10428] | Tenofovir alafenamide fumarate [DR:D10605])
Class
Antiviral
 DG03107  Anti-HIV agent
Remark
Therapeutic category: 6250
ATC code: J05AR22
Product: D11382<JP/US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Comment
Darunavir is a substrate of CYP3A; it is also an inhibitor of CYP3A, CYP2D6 and P-gp.
Cobicistat is an inhibitor of CYP3A and CYP2D6, and it is an inhibitor of the following transporters: P-gp, BCRP, OATP1B1 and OATP1B3. It is metabolized by CYP3A and CYP2D6.
Tenofovir alafenamide is a substrate of cathepsin A, CYP3A and P-gp.
Target
HIV protease [KO:K22599]
HIV-1 reverse transcriptase [KO:K24802]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR22 Emtricitabine, tenofovir alafenamide, darunavir and cobicistat
      D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Combinations
   Darunavir/ Cobicistat/ Emtricitabine/ Tenofovir Alafenamide Fumarate
    D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
Drug groups [BR:br08330]
 Antiviral
  DG03107  Anti-HIV agent
   D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
Antimicrobials [BR:br08307]
 Antivirals
  Polyprotein cleavage inhibitor
   HIV protease inhibitor
    D11382  Darunavir, cobicistat, emtricitabine and tenofovir alafenamide <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11382
Other DBs
PubChem: 384585360
LinkDB

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