KEGG   DRUG: Risdiplam
Entry
D11406                      Drug                                   

Name
Risdiplam (JAN/USAN/INN);
Evrysdi (TN)
Product
Formula
C22H23N7O
Exact mass
401.1964
Mol weight
401.4643
Structure
Remark
Product: D11406<US>
Efficacy
Protein modulator
  Disease
Spinal muscular atrophy [DS:H00455]
Comment
Treatment of Spinal muscular atrophy (SMA)
Target
SMN2 [HSA:6607] [KO:K13129]
  Pathway
hsa03013  RNA transport
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Signaling molecules
   Spliceosome
    SMN2
     D11406  Risdiplam (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11406
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11406
Other DBs
CAS: 1825352-65-5
PubChem: 384585384
ChEMBL: CHEMBL4297528
LinkDB
KCF data

ATOM        30
            1   N4y N    11.2000  -15.1900
            2   C8y C    11.2000  -16.5900
            3   C8y C    12.3900  -17.2900
            4   C8x C    13.6500  -16.5900
            5   C8y C    13.6500  -15.1900
            6   N5x N    12.3900  -14.4900
            7   C8x C     9.8700  -14.7700
            8   C8y C     9.0300  -15.8900
            9   N5x N     9.8700  -17.0100
            10  C1a C    12.3900  -18.6900
            11  C1a C     7.6300  -15.8900
            12  C8y C    14.8400  -14.4900
            13  N5x N    16.0300  -15.1900
            14  C8y C    17.2900  -14.4900
            15  N4y N    17.2900  -13.0900
            16  C8y C    16.1000  -12.3900
            17  C8x C    14.8400  -13.0900
            18  C8x C    18.4800  -15.1900
            19  C8x C    19.6700  -14.4900
            20  C8y C    19.6700  -13.0900
            21  C8x C    18.4800  -12.3900
            22  N1y N    20.8600  -12.3900
            23  C1x C    22.0500  -13.0900
            24  C1x C    23.3100  -12.3900
            25  N1x N    23.3100  -10.9900
            26  C1z C    22.1200  -10.2900
            27  C1x C    20.8600  -10.9900
            28  C1x C    22.8200   -9.1000
            29  C1x C    21.4200   -9.1000
            30  O5x O    16.1172  -10.9901
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    2   9 2
            11    3  10 1
            12    8  11 1
            13    5  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   12  17 2
            20   14  18 1
            21   18  19 2
            22   19  20 1
            23   20  21 2
            24   15  21 1
            25   20  22 1
            26   22  23 1
            27   23  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   22  27 1
            32   28  29 1
            33   29  26 1
            34   26  28 1
            35   16  30 2

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