KEGG   DRUG: Derazantinib hydrochloride
Entry
D11461                      Drug                                   
Name
Derazantinib hydrochloride (USAN);
Derazantinib dihydrochlororide
Formula
C29H29FN4O. 2HCl
Exact mass
540.1859
Mol weight
541.48
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Comment
Treatment of cancer
Target
FGFR [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095]
  Pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    D11461  Derazantinib hydrochloride
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR
     D11461  Derazantinib hydrochloride (USAN)
Other DBs
CAS: 1821329-75-2
LinkDB
KCF data

ATOM        37
            1   C8x C    28.0000  -18.1300
            2   C8x C    28.0000  -19.5300
            3   C8x C    26.8100  -20.2300
            4   C8y C    25.5500  -19.5300
            5   C8y C    25.5500  -18.1300
            6   C8x C    26.8100  -17.4300
            7   C1y C    24.3600  -17.4300
            8   X   F    24.3600  -20.2300
            9   C1x C    23.1700  -18.1300
            10  C8y C    21.9100  -17.4300
            11  C8y C    21.9100  -16.0300
            12  C8y C    23.1000  -15.3300
            13  C8y C    24.3600  -16.0300
            14  C8x C    23.1000  -13.9300
            15  C8x C    24.3600  -13.2300
            16  C8x C    25.5500  -13.9300
            17  C8x C    25.5500  -15.3300
            18  C8x C    20.7200  -18.1300
            19  N5x N    19.5300  -17.4300
            20  C8y C    19.5300  -16.0300
            21  N5x N    20.7200  -15.3300
            22  N1b N    18.3400  -15.3300
            23  C8y C    17.1500  -16.0300
            24  C8x C    17.1500  -17.4300
            25  C8x C    15.8900  -18.1300
            26  C8x C    14.7000  -17.4300
            27  C8y C    14.7000  -16.0300
            28  C8x C    15.8900  -15.3300
            29  C1b C    13.5100  -15.3300
            30  C1b C    12.3200  -16.0300
            31  N1b N    11.1300  -15.3300
            32  C1b C     9.9400  -16.0300
            33  C1b C     8.7500  -15.3300
            34  O2a O     7.5600  -16.0300
            35  C1a C     6.3700  -15.3300
            36  X   Cl   10.3600  -18.3400
            37  X   Cl   10.4300  -19.9500
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   5 1 #Down
            8     4   8 1
            9     7   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    7  13 1
            15   12  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 2
            20   10  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   11  21 2
            25   20  22 1
            26   22  23 1
            27   23  24 2
            28   24  25 1
            29   25  26 2
            30   26  27 1
            31   27  28 2
            32   23  28 1
            33   27  29 1
            34   29  30 1
            35   30  31 1
            36   31  32 1
            37   32  33 1
            38   33  34 1
            39   34  35 1

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