Homo sapiens (human): 2261
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Entry
2261 CDS
T01001
Symbol
FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4
Name
(RefSeq) fibroblast growth factor receptor 3
KO
K05094
fibroblast growth factor receptor 3 [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04144
Endocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04810
Regulation of actin cytoskeleton
hsa05200
Pathways in cancer
hsa05206
MicroRNAs in cancer
hsa05219
Bladder cancer
hsa05230
Central carbon metabolism in cancer
Network
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06261
Gastric cancer
nt06265
Bladder cancer
nt06270
Breast cancer
nt06526
MAPK signaling
nt06528
Calcium signaling
nt06530
PI3K signaling
Element
N00011
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00019
FGF-FGFR-RAS-ERK signaling pathway
N00037
FGF-FGFR-PI3K signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01599
Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL
N01641
RTK-PLCG-ITPR signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H00010
Multiple myeloma
H00020
Colorectal cancer
H00022
Bladder cancer
H00023
Testicular cancer
H00458
Syndromic craniosynostoses
H00505
FGFR3-related short limb skeletal dysplasia
H00642
Lacrimo-auriculo-dento-digital syndrome
H00997
CATSHL syndrome
H01749
Achondroplasia
H01750
Thanatophoric dysplasia
H01754
Crouzon syndrome
H01990
Muenke syndrome
H02068
Hypochondroplasia
H02069
SADDAN
H02627
Epidermal nevus
Drug target
Catequentinib (
DG03258
):
D12526
D12537
Derazantinib hydrochloride:
D11461
Dovitinib lactate:
D08907
Erdafitinib:
D10927
<JP/US>
Infigratinib (
DG03062
):
D11589
D11611
Lenvatinib (
DG01362
):
D09919
D09920
<JP/US>
Nintedanib (
DG01374
):
D10396
<JP/US>
D10481
Pemigatinib:
D11417
<JP/US>
Recifercept:
D12284
Repifermin:
D05716
Tasurgratinib (
DG03234
):
D12404
D12405
<JP>
Tinengotinib:
D12545
Vofatamab:
D11445
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
2261 (FGFR3)
04015 Rap1 signaling pathway
2261 (FGFR3)
04151 PI3K-Akt signaling pathway
2261 (FGFR3)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
2261 (FGFR3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
2261 (FGFR3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2261 (FGFR3)
05206 MicroRNAs in cancer
2261 (FGFR3)
05230 Central carbon metabolism in cancer
2261 (FGFR3)
09162 Cancer: specific types
05219 Bladder cancer
2261 (FGFR3)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
2261 (FGFR3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2261 (FGFR3)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hsa04090
]
2261 (FGFR3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
2261 (FGFR3)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
FGFR family [OT]
2261 (FGFR3)
CD molecules [BR:
hsa04090
]
Proteins
2261 (FGFR3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
I-set
Ig_3
ig
Ig_2
FGFR3_TM
V-set
C2-set_2
ABC1
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
2261
NCBI-ProteinID:
NP_000133
OMIM:
134934
HGNC:
3690
Ensembl:
ENSG00000068078
UniProt:
P22607
Q0IJ44
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:1793293..1808867
Genome browser
AA seq
806 aa
AA seq
DB search
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
NT seq
2421 nt
NT seq
+upstream
nt +downstream
nt
atgggcgcccctgcctgcgccctcgcgctctgcgtggccgtggccatcgtggccggcgcc
tcctcggagtccttggggacggagcagcgcgtcgtggggcgagcggcagaagtcccgggc
ccagagcccggccagcaggagcagttggtcttcggcagcggggatgctgtggagctgagc
tgtcccccgcccgggggtggtcccatggggcccactgtctgggtcaaggatggcacaggg
ctggtgccctcggagcgtgtcctggtggggccccagcggctgcaggtgctgaatgcctcc
cacgaggactccggggcctacagctgccggcagcggctcacgcagcgcgtactgtgccac
ttcagtgtgcgggtgacagacgctccatcctcgggagatgacgaagacggggaggacgag
gctgaggacacaggtgtggacacaggggccccttactggacacggcccgagcggatggac
aagaagctgctggccgtgccggccgccaacaccgtccgcttccgctgcccagccgctggc
aaccccactccctccatctcctggctgaagaacggcagggagttccgcggcgagcaccgc
attggaggcatcaagctgcggcatcagcagtggagcctggtcatggaaagcgtggtgccc
tcggaccgcggcaactacacctgcgtcgtggagaacaagtttggcagcatccggcagacg
tacacgctggacgtgctggagcgctccccgcaccggcccatcctgcaggcggggctgccg
gccaaccagacggcggtgctgggcagcgacgtggagttccactgcaaggtgtacagtgac
gcacagccccacatccagtggctcaagcacgtggaggtgaatggcagcaaggtgggcccg
gacggcacaccctacgttaccgtgctcaagacggcgggcgctaacaccaccgacaaggag
ctagaggttctctccttgcacaacgtcacctttgaggacgccggggagtacacctgcctg
gcgggcaattctattgggttttctcatcactctgcgtggctggtggtgctgccagccgag
gaggagctggtggaggctgacgaggcgggcagtgtgtatgcaggcatcctcagctacggg
gtgggcttcttcctgttcatcctggtggtggcggctgtgacgctctgccgcctgcgcagc
ccccccaagaaaggcctgggctcccccaccgtgcacaagatctcccgcttcccgctcaag
cgacaggtgtccctggagtccaacgcgtccatgagctccaacacaccactggtgcgcatc
gcaaggctgtcctcaggggagggccccacgctggccaatgtctccgagctcgagctgcct
gccgaccccaaatgggagctgtctcgggcccggctgaccctgggcaagccccttggggag
ggctgcttcggccaggtggtcatggcggaggccatcggcattgacaaggaccgggccgcc
aagcctgtcaccgtagccgtgaagatgctgaaagacgatgccactgacaaggacctgtcg
gacctggtgtctgagatggagatgatgaagatgatcgggaaacacaaaaacatcatcaac
ctgctgggcgcctgcacgcagggcgggcccctgtacgtgctggtggagtacgcggccaag
ggtaacctgcgggagtttctgcgggcgcggcggcccccgggcctggactactccttcgac
acctgcaagccgcccgaggagcagctcaccttcaaggacctggtgtcctgtgcctaccag
gtggcccggggcatggagtacttggcctcccagaagtgcatccacagggacctggctgcc
cgcaatgtgctggtgaccgaggacaacgtgatgaagatcgcagacttcgggctggcccgg
gacgtgcacaacctcgactactacaagaagacgaccaacggccggctgcccgtgaagtgg
atggcgcctgaggccttgtttgaccgagtctacactcaccagagtgacgtctggtccttt
ggggtcctgctctgggagatcttcacgctggggggctccccgtaccccggcatccctgtg
gaggagctcttcaagctgctgaaggagggccaccgcatggacaagcccgccaactgcaca
cacgacctgtacatgatcatgcgggagtgctggcatgccgcgccctcccagaggcccacc
ttcaagcagctggtggaggacctggaccgtgtccttaccgtgacgtccaccgacgagtac
ctggacctgtcggcgcctttcgagcagtactccccgggtggccaggacacccccagctcc
agctcctcaggggacgactccgtgtttgcccacgacctgctgcccccggccccacccagc
agtgggggctcgcggacgtga
DBGET
integrated database retrieval system