KEGG   DRUG: Infigratinib
Entry
D11589                      Drug                                   
Name
Infigratinib (USAN/INN)
Formula
C26H31Cl2N7O3
Exact mass
559.1865
Mol weight
560.4754
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03208  FGFR inhibitor
Remark
ATC code: L01EN03
Chemical structure group: DG03062
Efficacy
Antineoplastic, Angiogenesis inhibitor
Target
FGFR1 (CD331) [HSA:2260] [KO:K04362]
FGFR2 (CD332) [HSA:2263] [KO:K05093]
FGFR3 (CD333) [HSA:2261] [KO:K05094]
  Pathway
hsa04010  MAPK signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EN Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
     L01EN03 Infigratinib
      D11589  Infigratinib (USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     DG03062  Infigratinib
      D11589  Infigratinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR1 (CD331)
     D11589  Infigratinib (USAN/INN)
    FGFR2 (CD332)
     D11589  Infigratinib (USAN/INN)
    FGFR3 (CD333)
     D11589  Infigratinib (USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     DG03062  Infigratinib
Other DBs
CAS: 872511-34-7
PubChem: 405226456
PDB-CCD: 07J[PDBj]
LinkDB
KCF data

ATOM        38
            1   N1y N     5.3900  -15.8900
            2   C1x C     5.3900  -17.2900
            3   C1x C     6.6024  -17.9900
            4   N1y N     7.8149  -17.2900
            5   C1x C     7.8149  -15.8900
            6   C1x C     6.6024  -15.1900
            7   C1b C     4.1776  -15.1900
            8   C1a C     2.9821  -15.8804
            9   C8y C     9.0460  -18.0010
            10  C8x C     9.0457  -19.3899
            11  C8x C    10.2580  -20.0902
            12  C8y C    11.4706  -19.3905
            13  C8x C    11.4709  -18.0016
            14  C8x C    10.2586  -17.3013
            15  N1b N    12.6897  -20.0947
            16  C8y C    13.8894  -19.4023
            17  C8x C    15.0743  -20.0867
            18  C8y C    16.2869  -19.3870
            19  N5x N    16.2872  -17.9870
            20  C8x C    15.1023  -17.3025
            21  N5x N    13.8897  -18.0023
            22  N1c N    17.5177  -20.0981
            23  C5a C    18.7204  -19.4041
            24  C1a C    17.5173  -21.4899
            25  N1b N    19.9038  -20.0877
            26  O5a O    18.7211  -17.9903
            27  C8y C    21.0975  -19.3988
            28  C8y C    22.2853  -20.0850
            29  C8y C    23.4979  -19.3853
            30  C8x C    23.4983  -17.9853
            31  C8y C    22.3104  -17.2991
            32  C8y C    21.0978  -17.9988
            33  X   Cl   22.2851  -21.4898
            34  O2a O    22.3106  -15.8901
            35  C1a C    23.5377  -15.1818
            36  O2a O    24.7287  -20.0964
            37  C1a C    25.9300  -19.4032
            38  X   Cl   19.8610  -17.2841
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   18  22 1
            25   22  23 1
            26   22  24 1
            27   23  25 1
            28   23  26 2
            29   25  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   27  32 1
            36   28  33 1
            37   31  34 1
            38   34  35 1
            39   29  36 1
            40   36  37 1
            41   32  38 1

» Japanese version   » Back

DBGET integrated database retrieval system