KEGG   DRUG: Omeprazole and sodium bicarbonate
Entry
D11706            Mixture   Drug                                   
Name
Omeprazole and sodium bicarbonate;
Zegerid (TN)
Product
KONVOMEP (Azurity Pharmaceuticals), ZEGERID (Santarus)
  Generic
OMEPRAZOLE AND SODIUM BICARBONATE (ANI Pharmaceuticals), OMEPRAZOLE AND SODIUM BICARBONATE (Ajanta Pharma USA), OMEPRAZOLE AND SODIUM BICARBONATE (Ajanta Pharma USA), OMEPRAZOLE AND SODIUM BICARBONATE (Bryant Ranch Prepack), OMEPRAZOLE AND SODIUM BICARBONATE (Bryant Ranch Prepack), OMEPRAZOLE AND SODIUM BICARBONATE (Oceanside Pharmaceuticals), OMEPRAZOLE AND SODIUM BICARBONATE (PHOENIX RX LLC), OMEPRAZOLE AND SODIUM BICARBONATE (PHOENIX RX LLC), OMEPRAZOLE AND SODIUM BICARBONATE (ScieGen Pharmaceuticals), OMEPRAZOLE SODIUM BICARBONATE (Cipla USA), OMEPRAZOLE, SODIUM BICARBONATE (Bryant Ranch Prepack), OMEPRAZOLE, SODIUM BICARBONATE (Bryant Ranch Prepack), OMEPRAZOLE, SODIUM BICARBONATE (Guardian Drug Company), OMEPRAZOLE/BICARBONATE (Proficient Rx LP), OMEPRAZOLE/BICARBONATE (Westminster Pharmaceuticals), OMEPRAZOLE/SODIIUM BICARBONATE (Direct_rx), OMEPRAZOLE/SODIUM BICARBONATE (Strides Pharma Science Limited)
Component
Omeprazole [DR:D00455], Sodium bicarbonate [DR:D01203]
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Product: D11706<US>
Efficacy
Anti-ulcerative
  Disease
Duodenal ulcer [DS:H01634]
Gastric ulcer [DS:H01634]
Gastroesophageal reflux disease [DS:H01602]
Comment
Omeprazole is metabolized by CYP2C19 with some contribution from CYP3A4.
Metabolism
Enzyme: CYP2C19 [HSA:1557]; CYP3A4 [HSA:1576]
Interaction
Brite
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Omeprazole/ Sodium Bicarbonate
    D11706  Omeprazole and sodium bicarbonate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D11706  Omeprazole and sodium bicarbonate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11706  Omeprazole and sodium bicarbonate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11706
Other DBs
CAS: 774595-73-2
PubChem: 405226572
LinkDB

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