KEGG   DRUG: Concizumab
Entry
D11847                      Drug                                   
Name
Concizumab (USAN);
Concizumab (genetical recombination) (JAN);
Concizumab-mtci;
Alhemo (TN)
Product
Formula
C6462H10004N1712O2046S46
Exact mass
145795.8549
Mol weight
145885.89
Sequence
(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGFTFS NYAMSWVRQT PEKRLEWVAT ISRSGSYSYF
PDSVQGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARLG GYDEGDAMDS WGQGTTVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE SKYGPPCPPC PAPEFLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY TLPPSQEEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSR LTVDKSRWQE
GNVFSCSVMH EALHNHYTQK SLSLSLGK
(Light chain)
DIVMTQTPLS LSVTPGQPAS ISCKSSQSLL ESDGKTYLNW YLQKPGQSPQ LLIYLVSILD
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCLQATHFP QTFGGGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H135-L219, H148-H204, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'135-L'219, H'148-H'204, H'262-H'322, H'368-H'426, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Remark
Therapeutic category: 6349
ATC code: B02BX10
Product: D11847<JP/US>
Efficacy
Bleeding suppressant, Anti-tissue factor pathway inhibitor antibody
  Disease
Hemophilia A [DS:H00219]
Hemophilia B [DS:H00219]
  Type
Monoclonal antibody
Comment
Prevention of bleeding episodes in hemophilia A and B
Target
TFPI [HSA:7035] [KO:K03909]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX10 Concizumab
      D11847  Concizumab (USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6349  Others
     D11847  Concizumab (USAN); Concizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Peptidase inhibitors
   Kunitz/BPTI family
    TFPI
     D11847  Concizumab (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11847
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11847
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11847
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11847
Other DBs
CAS: 1312299-39-0
PubChem: 433774522
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system