KEGG ORTHOLOGY: K03909

ORTHOLOGY: K03909

Entry

K03909                      KO

Symbol

TFPI

Name

tissue factor pathway inhibitor

Pathway

map04610

Complement and coagulation cascades

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03909  TFPI; tissue factor pathway inhibitor
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03909  TFPI; tissue factor pathway inhibitor
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K03909  TFPI; tissue factor pathway inhibitor
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   K03909  TFPI; tissue factor pathway inhibitor
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   K03909  TFPI; tissue factor pathway inhibitor

Other DBs

GO:

0004867

Genes

HSA:	7035(TFPI)

PTR:	470603(TFPI)

PPS:	100974935(TFPI)

GGO:	101150295(TFPI)

PON:	100171528(TFPI)

PPYG:

129031242(TFPI)

NLE:	100604816(TFPI)

HMH:	116810560(TFPI)

SSYN:

129488158(TFPI)

MCC:	613026(TFPI)

MCF:	102119734(TFPI)

MTHB:

126932740

MNI:	105468250(TFPI)

CSAB:

103217493(TFPI)

CATY:

105579927(TFPI)

PANU:

101021304(TFPI)

TGE:	112636101(TFPI)

MLEU:

105553898(TFPI)

RRO:	104667750(TFPI)

RBB:	108535422(TFPI)

TFN:	117094749(TFPI)

PTEH:

111542818(TFPI)

CANG:

105507803(TFPI)

CJC:	100391706(TFPI)

SBQ:	101041187(TFPI)

CIMI:

108315625(TFPI)

ANAN:

105725140(TFPI)

CSYR:

103276413(TFPI)

MMUR:

105879303(TFPI)

LCAT:

123643562(TFPI)

PCOQ:

105825750(TFPI)

OGA:	100960539(TFPI)

MMU:	21788(Tfpi)

MCAL:

110288305(Tfpi)

MPAH:

110318900(Tfpi)

RNO:	29436(Tfpi)

MCOC:

116090390(Tfpi)

ANU:	117703829(Tfpi)

ASYL:

127685529(Tfpi)

MUN:	110551966(Tfpi)

CGE:	100760115(Tfpi)

MAUA:

101825370(Tfpi)

PROB:

127222343(Tfpi)

PLEU:

114701612(Tfpi)

MORG:

121439312(Tfpi)

MFOT:

126487620

AAMP:

119819144(Tfpi)

NGI:	103728762(Tfpi)

HGL:	101710461(Tfpi)

CPOC:

100727170(Tfpi)

CCAN:

109698481(Tfpi)

DORD:

105996471(Tfpi)

DSP:	122115052(Tfpi)

DMER:

138825081(Tfpi)

PLOP:

125350482(Tfpi)

NCAR:

124980760

MMMA:

107138531(Tfpi)

ITI:	101960090(Tfpi)

OCU:	100009401(TFPI)

OPI:	101534178(TFPI)

TUP:	102493222(TFPI)

GVR:	103590694(TFPI)

CFA:	403921(TFPI)

CLUD:

112668244(TFPI)

VVP:	112931061(TFPI)

VLG:	121471992(TFPI)

NPO:	129498935(TFPI)

AML:	100467371(TFPI)

UMR:	103659659(TFPI)

UAH:	113250680(TFPI)

UAR:	123798120(TFPI)

ELK:

111145643

LLV:

125095218

MPUF:

101693601(TFPI)

MNP:	132013373(TFPI)

MLK:	131827683(TFPI)

NVS:	122902100(TFPI)

ORO:	101370650(TFPI)

EJU:	114225315(TFPI)

ZCA:	113919346(TFPI)

MLX:	118012233(TFPI)

NSU:	110592213(TFPI)

LWW:	102750664(TFPI)

FCA:	101098813(TFPI)

PYU:	121030807(TFPI)

PCOO:

112848944(TFPI)

PBG:	122481549(TFPI)

PVIV:

125173758(TFPI)

LRUF:

124515924

LGF:	123599197(TFPI)

AJU:

106976531

PTG:	102967553(TFPI)

PPAD:

109274268(TFPI)

PUC:

125911485

PLEZ:

122226368(TFPI)

HHV:	120241463(TFPI)

BTA:	508763(TFPI)

BOM:	102280267(TFPI)

BIU:	109565684(TFPI)

BBUB:

102409335(TFPI)

BBIS:

105002882(TFPI)

CHX:	102185317(TFPI)

OAS:	101120391(TFPI)

BTAX:

128043753(TFPI)

CSUM:

138075992(TFPI)

ODA:	120854014(TFPI)

CCAD:

122453847(TFPI)

MREE:

136165456(TFPI)

OVR:	110147154(TFPI)

MBEZ:

129538434(TFPI)

SSC:	100155068(TFPI)

CFR:	102507096(TFPI)

CBAI:

105072913(TFPI)

CDK:	105099010(TFPI)

VPC:	102536993(TFPI)

BACU:

103003675(TFPI)

BMUS:

118898332(TFPI)

LVE:	103085229(TFPI)

OOR:	101287826(TFPI)

LALB:

132522237(TFPI)

GMF:	115849117(TFPI)

DLE:	111171643(TFPI)

PCAD:

102989097(TFPI)

PSIU:

116756702(TFPI)

PPHC:

136125957(TFPI)

NASI:

112400364(TFPI)

ECB:	100068873(TFPI)

EPZ:	103549925(TFPI)

EAI:	106838694(TFPI)

MLF:	102437311 102437918

MDT:	132238785 132238786

EFUS:

103290651(TFPI)

MNA:	107524072(TFPI)

DRO:	112305840(TFPI) 112305841

SHON:

118985324(TFPI)

AJM:	119062136(TFPI)

PDIC:

114494809(TFPI)

PHAS:

123805976(TFPI)

MMF:	118625022(TFPI)

PPAM:

129061952(TFPI)

HAI:	109372705(TFPI)

RFQ:	117025452(TFPI)

PALE:

102880882(TFPI)

PGIG:

120597565(TFPI)

PVP:	105289636(TFPI)

RAY:	107513608(TFPI)

MJV:	108389700(TFPI)

TOD:	119256016(TFPI)

SARA:

101553832(TFPI)

SFUM:

130021143(TFPI)

SETR:

126009014(TFPI)

LAV:	100670685(TFPI)

TMU:

101359751

ETF:	101652919(TFPI)

DNM:	101445919(TFPI)

MDO:	100028266(TFPI)

GAS:	123242167(TFPI)

SHR:	100932876(TFPI)

AFZ:

127554486

PCW:	110201717(TFPI)

TVP:	118838187(TFPI)

PBRV:

138143316(TFPI)

MLAO:

141507655(TFPI)

OAA:	100086245(TFPI)

TACU:

119932369(TFPI) 119939393

GGA:	423989(TFPI)

PCOC:

116235939(TFPI)

MGP:	100542380(TFPI)

CJO:	107316437(TFPI)

TPAI:

128077367(TFPI)

LMUT:

125697161(TFPI)

NMEL:

110399465(TFPI)

APLA:

101794822(TFPI)

ACYG:

106034541(TFPI)

CATA:

118259613(TFPI)

AFUL:

116490468(TFPI)

TGU:	100228168(TFPI)

LSR:	110476181(TFPI)

SCAN:

103814557(TFPI)

PMOA:

120511539(TFPI)

OTC:	121335449(TFPI)

PRUF:

121364390(TFPI)

ATRC:

139593510(TFPI)

GFR:	102036504(TFPI)

FAB:	101808152(TFPI)

OMA:	130255469(TFPI)

PHI:	102112768(TFPI)

PMAJ:

107207694(TFPI)

CCAE:

111931911 111931912

CCW:	104693724(TFPI)

CBRC:

103612584(TFPI)

ACOE:

138113530(TFPI)

ETL:	114057771(TFPI)

ZAB:	102065897(TFPI)

ZLE:	135450513(TFPI)

ACHL:

103804278(TFPI)

SVG:	106855939(TFPI)

MMEA:

130583829(TFPI)

HRT:	120755399(TFPI)

SATI:

136363344(TFPI)

CCIC:

134052352(TFPI)

FPG:	101913841(TFPI)

FCH:	102058471(TFPI)

CCRI:

104162377(TFPI)

NNT:

104400965

SHAB:

115608427(TFPI)

ACUN:

113482427(TFPI)

TALA:

104366866(TFPI)

ACHC:

115343214(TFPI)

HALD:

104316269

HLE:	104841514(TFPI)

HHAR:

128144625(TFPI)

GCL:

127018260

CSTI:

104560852

LDI:	104352295(TFPI)

MNB:	103775402(TFPI)

DPUB:

104309849(TFPI)

PPUS:

135183211(TFPI)

BRHI:

104493424 104500464

EGZ:	104130556(TFPI)

NNI:	104015298(TFPI)

PCRI:

104025924

PCAO:

104052449

PADL:

103926163(TFPI)

AFOR:

103908572(TFPI)

FGA:

104077050

GSTE:

104259183(TFPI)

CBOY:

140657291(TFPI)

CLV:	102096856(TFPI)

CNIC:

135990315(TFPI)

MUI:	104543802(TFPI)

PGUU:

104462598 104471010

PLET:

104619369

EHS:	104506125(TFPI)

CMAC:

104478860

CUCA:

104065350 128849181(TFPI)

TEO:	104378008(TFPI)

BREG:

104641616(TFPI)

OHA:	104328403(TFPI)

ACAR:

104522482(TFPI)

CPEA:

104386604(TFPI)

CVF:	104290945(TFPI)

RTD:	128912694(TFPI)

CRID:

134518731(TFPI)

AAM:	106499287(TFPI)

AROW:

112967679(TFPI)

NPD:	112942748(TFPI)

TGT:	104571881(TFPI)

DNE:	112979922(TFPI)

SCAM:

104138612(TFPI)

ASN:	102388104(TFPI) 112551386

AMJ:	102572762(TFPI) 109280193

CPOO:

109313292 109323023(TFPI)

GGN:	109292347 109301830(TFPI)

PSS:	102457418(TFPI)

CMY:	102938937(TFPI)

CCAY:

125644810(TFPI)

DCC:	119863414(TFPI)

CPIC:

101945146(TFPI)

TST:	117884715(TFPI)

CABI:

116831346(TFPI)

MRV:	120374678(TFPI) 120380398

ACS:	100556464(tfpi) 103280506

ASAO:

132777817(TFPI)

PVT:	110088390(TFPI)

SUND:

121918947(TFPI)

PBI:	103065787(TFPI)

PMUR:

107297037(TFPI)

CTIG:

120310470(TFPI)

TSR:	106550122(TFPI)

PGUT:

117672490(TFPI)

PCAE:

139313903 139315132 139327146(TFPI)

APRI:

131195105 131201249(TFPI)

PTEX:

113434014(TFPI)

NSS:	113412416(TFPI)

VKO:	123021824(TFPI)

PMUA:

114584614(TFPI)

PRAF:

128398795(TFPI) 128402909

ZVI:	118083983(TFPI)

HCG:	128334876(TFPI)

GJA:	107117285(TFPI)

STOW:

125443757(TFPI)

EMC:	129323631(TFPI)

PWL:	138285613(TFPI)

MUO:	115474581(TFPI)

GSH:	117361364(TFPI)

DRE:	359833(tfpia)

SRX:	107714394 107728931 107751556 107752315 107757752

SANH:

107657515 107659476 107660650 107665773 107698374

SGH:	107568604 107573404 107584163 107598915 107602164

CCAR:

109050768 109062260

CAUA:

113053705 113108344

CGIB:

127964833

PTET:

122351549(tfpia)

LROH:

127170416(tfpia)

GRF:	141340412(tfpia)

OMC:	131546804(tfpia)

PPRM:

120459791(tfpia)

RKG:	130100287(tfpia)

MAMB:

125270639(tfpia)

CIDE:

127519274

CERY:

137035741(tfpia)

MASI:

127447332 127447927

TROS:

130556070(tfpia)

TDW:	130427349(tfpia)

MANU:

129451660(tfpia)

PDAB:

135733506(tfpia)

IPU:	108266850(tfpia) 108277053(wu:fb59d01)

IFU:	128608500(tfpia)

PHYP:

113526146 113544736

SMEO:

124383141(tfpia)

TFD:	113650663(tfpia)

TVC:	132850496(tfpia)

CGAR:

128524097(tfpia)

NGRA:

132891423(tfpia)

TRN:	134324096(tfpia)

AMEX:

103025270(tfpia)

CMAO:

118812465(tfpia)

EEE:	113573332 113584795

CHAR:

105905913(tfpia)

SPIL:

134078322(tfpia)

TRU:

101078065

TFS:	130526749(tfpia)

LCO:

104930424

NCC:

104940995

TBEN:

117485702(tfpia)

CGOB:

115026134

PGEO:

117466704(tfpia)

GACU:

117549516(tfpia)

EMAC:

134867738(tfpia)

ELY:	117251731(tfpia)

EFO:	125899733(tfpia)

PLEP:

121949318

SLUC:

116047623(tfpia)

ECRA:

117952910(tfpia)

ESP:

116698190

PFLV:

114564333

GAT:	120833791(tfpia)

PPUG:

119228351(tfpia)

AFB:	129104571(tfpia)

CLUM:

117750442(tfpia)

PSWI:

130200199(tfpia)

CANA:

137782934(tfpia)

CVE:	137868379(tfpia)

MSAM:

119903831(tfpia)

SCHU:

122885787(tfpia)

CUD:	121522770(tfpia)

SPUL:

138592423(tfpia)

LMIX:

132987554(tfpia)

ALAT:

119026315(tfpia)

ASTR:

137605315(tfpia)

MZE:

101471591

ONL:

112844144

OAU:	116334051(tfpia)

OLA:

101174546

OML:	112154769(tfpia)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122839551(tfpia)

PPRL:

129374453

CVG:

107086197

CTUL:

119782131(tfpia)

GMU:

124870970

NFU:

107397072

KMR:	108244305(tfpia)

ALIM:

106532916

NWH:	119418999(tfpia)

AOCE:

111571402(tfpia)

EJA:	138201389(tfpia)

BFRE:

138621071(tfpia)

MCEP:

125017898(tfpia)

CSEM:

103392428

POV:

109637428

SSEN:

122759106(tfpia)

SSOE:

131445296(tfpia)

HHIP:

117755105(tfpia)

HSP:	118120486(tfpia)

PPLT:

128455672(tfpia)

SMAU:

118282773(tfpia)

LCF:

108887694

SDU:

111218786

SLAL:

111667394

XGL:	120801667(tfpia)

HCQ:

109515452

SSCV:

125973612(tfpia)

SBIA:

133512132(tfpia)

PEE:	133410499(tfpia)

PTAO:

133486883(tfpia)

BPEC:

110175845

ENY:

140348330

MALB:

109972631

BSPL:

114847483(tfpia)

SJO:	128368445(tfpia)

SSCO:

133993098(tfpia)

GMH:

115533316

SASA:

106581931 106586828

STRU:

115155937 115161320

OTW:	112219840 112225305 112242803(tfpia)

OMY:	110501376 110520593 110523631

OGO:	124043808 124044238(tfpia)

ONE:	115110561 115113431

OKI:	109870748 109871074

OKE:	118366718 118386114

OMM:	135518969(tfpia) 135547292

OCLA:

139380087 139405496

SALP:

111959803 111961568 111980273

SNH:	120058000 120063990

CCLU:

121536481(tfpia) 121556407

ELS:	105007056 105021910

OEP:	134017061(tfpia)

SFM:	108924250 108928720

PKI:

111838657

AANG:

118214619(tfpia)

AROT:

135240685(tfpia)

CCOG:

133116876(tfpia)

LOC:	102697566(tfpi)

PSPA:

121322162 121323099

ARUT:

117403550 117426098

PSEX:

120531988(tfpia)

LCM:	102363540(TFPI)

CMK:	103176522(tfpia)

RTP:

109931976

CPLA:

122556847

HOC:	132817511(tfpia)

HAKA:

140728386

BFO:

118416449

CIN:	100178954 100179019

SCLV:

AJJ:

DHE:

CVJ:

CLON:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:	106113642 106122350

BPHI:

ZCE:

LSIN:

HAW:

TNL:	113492019 113493868

OFU:

114365016

ONU:

135076459

ATRA:

106136551

PGW:	126370367 126380265

CFUM:

141433902 141434170

HAMR:

139693403

FCD:	110842102 110861324

DPX:	DAPPUDRAFT_303666

DMK:	116915825 116921946 123470050 123470166

HAME:

121863070 121863105

EAF:

111710527

LSM:	121116673 121126190

TCF:

131886835

DSV:

119458997

RSAN:

119373300 119374378 119374898 119374899 119375216 119376578 119388909 119402771

RMP:	119165320 119167580 119167920 119168433 119168434 119185965

CSCU:

CVS:

PTEP:

ABRU:

SDM:

LPOL:

NAI:	NECAME_03769 NECAME_15061

GAE:

121372375

HRF:	124146564 124150129

HRJ:	124275544 124282142 124285436

HASI:

137294924 137298346

HCRA:

139443769 139444097 139464131

CRG:

CANU:

CVN:

OED:

PMAX:

AIRR:

MMER:

123548108 123566367 123566375

RPHI:

132726139 132750962 132751743

MAEA:

LAK:

NVE:

EPA:

Reference

PMID:2452157

Authors

Wun TC, Kretzmer KK, Girard TJ, Miletich JP, Broze GJ Jr

Title

Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.

Journal

J Biol Chem 263:6001-4 (1988)

Sequence

[hsa:7035]

Reference

PMID:24127605

Authors

Wood JP, Bunce MW, Maroney SA, Tracy PB, Camire RM, Mast AE

Title

Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation.

Journal

Proc Natl Acad Sci U S A 110:17838-43 (2013)
DOI:10.1073/pnas.1310444110

LinkDB

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