コンシズマブ (遺伝子組換え) (JAN);
Concizumab (USAN);
Concizumab (genetical recombination) (JAN)

C6462H10004N1712O2046S46

145795.8549

145885.808

(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGFTFS NYAMSWVRQT PEKRLEWVAT ISRSGSYSYF
PDSVQGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARLG GYDEGDAMDS WGQGTTVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE SKYGPPCPPC PAPEFLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY TLPPSQEEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSR LTVDKSRWQE
GNVFSCSVMH EALHNHYTQK SLSLSLGK
(Light chain)
DIVMTQTPLS LSVTPGQPAS ISCKSSQSLL ESDGKTYLNW YLQKPGQSPQ LLIYLVSILD
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCLQATHFP QTFGGGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H135-L219, H148-H204, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'135-L'219, H'148-H'204, H'262-H'322, H'368-H'426, L23-L93, L139-L199, L'23-L'93, L'139-L'199)

出血抑制, 抗組織因子経路阻害抗体

希少疾病用医薬品指定: インヒビターを保有する先天性血液凝固第VIII因子又は第IX因子欠乏患者の出血傾向の抑制 [DS:H00219]

TFPI [HSA:7035] [KO:K03909]