KEGG   DRUG: Daridorexant hydrochloride
Entry
D11887                      Drug                                   
Name
Daridorexant hydrochloride (JAN/USAN);
Quviviq (TN)
Product
Formula
C23H23ClN6O2. HCl
Exact mass
486.1338
Mol weight
487.3817
Structure
Class
Neuropsychiatric agent
 DG03225  Orexin receptor antagonist
Remark
Chemical structure group: DG03119
Product (DG03119): D11887<US>
Efficacy
Hypnotic, Orexin receptor antagonist
  Disease
Insomnia [DS:H01609]
Comment
Treatment of insomnia disorder in adult patients
Target
HCRTR [HSA:3061 3062] [KO:K04238 K04239]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03225  Orexin receptor antagonist
   DG03119  Daridorexant
    D11887  Daridorexant hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Orexin
    HCRTR
     D11887  Daridorexant hydrochloride (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11887
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11887
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11887
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03225  Orexin receptor antagonist
   DG03119  Daridorexant
Other DBs
CAS: 1792993-84-0
LinkDB
KCF data

ATOM        33
            1   C1x C    16.7455  -14.3633
            2   C1x C    16.7455  -15.7645
            3   C1z C    18.0767  -16.1849
            4   N1y N    18.9175  -15.0639
            5   C1x C    18.0767  -13.9429
            6   C5a C    20.3187  -15.0639
            7   O5a O    21.0194  -16.3251
            8   C8y C    21.0194  -13.8728
            9   C8y C    22.4207  -13.8728
            10  C8x C    23.1213  -12.6817
            11  C8x C    22.4207  -11.4205
            12  C8x C    21.0194  -11.4205
            13  C8y C    20.3187  -12.6817
            14  O2a O    18.9175  -12.6817
            15  N4y N    23.1213  -15.0639
            16  N5x N    22.7009  -16.3951
            17  C8x C    23.8220  -17.2359
            18  C8x C    24.9430  -16.4652
            19  N5x N    24.5226  -15.1340
            20  C1a C    18.2168  -11.4906
            21  C1a C    19.2678  -16.8856
            22  C8y C    16.8856  -16.8856
            23  N5x N    16.7455  -18.2869
            24  C8y C    15.2741  -18.5671
            25  C8y C    14.6435  -17.3060
            26  N4x N    15.5544  -16.3251
            27  C8x C    13.2422  -17.3060
            28  C8x C    12.5416  -18.4971
            29  C8y C    13.1722  -19.6882
            30  C8y C    14.5734  -19.7582
            31  X   Cl   12.4014  -20.9493
            32  C1a C    15.2040  -20.9493
            33  X   Cl   23.4500  -20.7200
BOND        36
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     4   6 1
            7     6   7 2
            8     6   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   13  14 1
            16    9  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   15  19 1
            22   14  20 1
            23    3  21 1 #Up
            24    3  22 1 #Down
            25   22  23 2
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   22  26 1
            30   25  27 2
            31   27  28 1
            32   28  29 2
            33   29  30 1
            34   24  30 2
            35   29  31 1
            36   30  32 1

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