KEGG   DRUG: Mobocertinib succinate
Entry
D11969                      Drug                                   

Name
Mobocertinib succinate (JAN);
Exkivity (TN)
Formula
C32H39N7O4. C4H6O4
Exact mass
703.333
Mol weight
703.7846
Structure
Remark
Chemical structure group: DG03148
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Non-small cell lung cancer (EGFR exon 20 insertion mutation) [DS:H00014]
Target
EGFR* [HSA_VAR:1956v2] [HSA:1956] [KO:K04361]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR* [HSA_VAR:1956v2]
     D11969  Mobocertinib succinate (JAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11969
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11969
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11969
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11969
LinkDB
KCF data

ATOM        51
            1   C8y C    19.3101  -20.0765
            2   C8y C    20.5691  -19.3770
            3   C8x C    20.5691  -17.9781
            4   C8y C    19.3800  -17.2786
            5   C8y C    18.1210  -17.9781
            6   C8x C    18.1210  -19.3770
            7   N1b N    16.9319  -17.2786
            8   C8y C    16.9319  -15.8797
            9   N5x N    18.1909  -15.1802
            10  C8x C    18.1909  -13.7813
            11  C8y C    16.9319  -13.0818
            12  C8y C    15.7428  -13.7813
            13  N5x N    15.7428  -15.1802
            14  C8y C    14.5537  -13.0818
            15  O2a O    19.3800  -15.8797
            16  C1a C    20.5691  -15.1802
            17  C8x C    14.2739  -11.6829
            18  N4y N    12.8750  -11.5430
            19  C8y C    12.3154  -12.8020
            20  C8y C    13.2947  -13.7113
            21  C8x C    10.9864  -13.2217
            22  C8x C    10.6367  -14.5507
            23  C8x C    11.6859  -15.5299
            24  C8x C    13.0149  -15.1103
            25  C1a C    12.1755  -10.2839
            26  N1c N    21.7582  -20.0765
            27  C1a C    21.7582  -21.4754
            28  C1b C    22.9473  -19.4470
            29  N1b N    19.3101  -21.4754
            30  C5a C    18.1210  -22.1749
            31  C2b C    16.8620  -21.4754
            32  O5a O    18.1210  -23.5738
            33  C1b C    24.2064  -20.1464
            34  N1c N    25.3955  -19.4470
            35  C1a C    26.5846  -20.1464
            36  C1a C    25.3955  -18.0480
            37  C2a C    15.6729  -22.1749
            38  C7a C    16.9319  -11.6829
            39  O7a O    15.7428  -10.9134
            40  O6a O    18.1210  -10.9134
            41  C1c C    15.7428   -9.5145
            42  C1a C    14.4838   -8.8150
            43  C1a C    16.9319   -8.8150
            44  C6a C    26.3900  -12.8800
            45  C1b C    27.6024  -13.5800
            46  O6a O    25.1776  -13.5800
            47  C1b C    28.7979  -12.8896
            48  C6a C    29.9853  -13.5751
            49  O6a O    31.1765  -12.8871
            50  O6a O    29.9855  -14.9798
            51  O6a O    26.3900  -11.4800
BOND        53
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   12  14 1
            16    4  15 1
            17   15  16 1
            18   14  17 2
            19   17  18 1
            20   18  19 1
            21   19  20 2
            22   14  20 1
            23   19  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   20  24 1
            28   18  25 1
            29    2  26 1
            30   26  27 1
            31   26  28 1
            32    1  29 1
            33   29  30 1
            34   30  31 1
            35   30  32 2
            36   28  33 1
            37   33  34 1
            38   34  35 1
            39   34  36 1
            40   31  37 2
            41   11  38 1
            42   38  39 1
            43   38  40 2
            44   39  41 1
            45   41  42 1
            46   41  43 1
            47   44  45 1
            48   44  46 1
            49   45  47 1
            50   47  48 1
            51   48  49 1
            52   48  50 2
            53   44  51 2

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