KEGG   VARIANT: 1956v2
Entry
1956v2                      Variant                                
Name
EGFR mutation in non-small cell lung cancer
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
exon 19 deletion
ClinVar: 177620
dbSNP: rs727504233
Variation
Variation
exon 20 insertion
ClinVar: 45263
dbSNP: rs1554350366
Variation
TKI-resistant mutation T790M
ClinVar: 16613
dbSNP: rs121434569
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06220  Calcium signaling (cancer)
nt06266  Non-small cell lung cancer
nt06526  MAPK signaling
nt06528  Calcium signaling
nt06530  PI3K signaling
Disease
H00014  Non-small cell lung cancer
H00042  Glioma
Drug target
Afatinib (DG00717): D09733<JP/US>
Amivantamab: D11894<US>
Aumolertinib (DG03209): D12258 D12259
Dacomitinib (DG01793): D10514<JP/US>
Erlotinib (DG00711): D04023<JP/US>
Firmonertinib (DG03322): D12956 D12957
Gefitinib: D01977<JP/US>
Lazertinib (DG03205): D11980 D12245<US>
Mobocertinib (DG03148): D11969<US>
Osimertinib: D10766<JP/US>
Pebezertinib: D12859
Sunvozertinib: D12506
Tigozertinib: D12730
Reference
  Authors
Toyooka S, Mitsudomi T, Soh J, Aokage K, Yamane M, Oto T, Kiura K, Miyoshi S
  Title
Molecular oncology of lung cancer.
  Journal
Gen Thorac Cardiovasc Surg 59:527-37 (2011)
DOI:10.1007/s11748-010-0743-3
Reference
  Authors
Lee DH
  Title
Treatments for EGFR-mutant non-small cell lung cancer (NSCLC): The road to a success, paved with failures.
  Journal
Pharmacol Ther 174:1-21 (2017)
DOI:10.1016/j.pharmthera.2017.02.001
Reference
  Authors
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA.
  Title
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
  Journal
N Engl J Med 350:2129-39 (2004)
DOI:10.1056/NEJMoa040938
Reference
  Authors
Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M
  Title
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
  Journal
PLoS Med 2:e313 (2005)
DOI:10.1371/journal.pmed.0020313
Reference
  Authors
Yasuda H, Kobayashi S, Costa DB
  Title
EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.
  Journal
Lancet Oncol 13:e23-31 (2012)
DOI:10.1016/S1470-2045(11)70129-2
Reference
  Authors
Sullivan I, Planchard D
  Title
Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line.
  Journal
Front Med (Lausanne) 3:76 (2016)
DOI:10.3389/fmed.2016.00076
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