| Entry |
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| Name |
EGFR mutation in non-small cell lung cancer
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| Type |
Gain of function
|
| Gene |
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| Organism |
hsa_var Human gene variants (Homo sapiens)
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| Variation |
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| Variation |
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| Variation |
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| Variation |
|
| Network |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Drug target |
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| Reference |
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| Authors |
Toyooka S, Mitsudomi T, Soh J, Aokage K, Yamane M, Oto T, Kiura K, Miyoshi S |
| Title |
Molecular oncology of lung cancer. |
| Journal |
|
| Reference |
|
| Authors |
Lee DH |
| Title |
Treatments for EGFR-mutant non-small cell lung cancer (NSCLC): The road to a success, paved with failures. |
| Journal |
|
| Reference |
|
| Authors |
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA. |
| Title |
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. |
| Journal |
|
| Reference |
|
| Authors |
Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M |
| Title |
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. |
| Journal |
|
| Reference |
|
| Authors |
Yasuda H, Kobayashi S, Costa DB |
| Title |
EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. |
| Journal |
|
| Reference |
|
| Authors |
Sullivan I, Planchard D |
| Title |
Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. |
| Journal |
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| LinkDB |
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