KEGG   VARIANT: 1956v2
Entry
1956v2                      Variant                                

Name
EGFR mutation in non-small cell lung cancer
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
exon 19 deletion
ClinVar: 177620
dbSNP: rs727504233
Variation
Variation
exon 20 insertion
ClinVar: 45263
dbSNP: rs1554350366
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06220  Calcium signaling
nt06266  Non-small cell lung cancer
  Element
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N10005  First/second-generation tyrosine kinase inhibitor to EGFR mutation
Drug target
Afatinib (DG00717): D09733<JP/US>
Amivantamab: D11894<US>
Dacomitinib (DG01793): D10514<JP/US>
Erlotinib (DG00711): D04023<JP/US>
Gefitinib: D01977<JP/US>
Reference
  Authors
Toyooka S, Mitsudomi T, Soh J, Aokage K, Yamane M, Oto T, Kiura K, Miyoshi S
  Title
Molecular oncology of lung cancer.
  Journal
Gen Thorac Cardiovasc Surg 59:527-37 (2011)
DOI:10.1007/s11748-010-0743-3
Reference
  Authors
Lee DH
  Title
Treatments for EGFR-mutant non-small cell lung cancer (NSCLC): The road to a success, paved with failures.
  Journal
Pharmacol Ther 174:1-21 (2017)
DOI:10.1016/j.pharmthera.2017.02.001
Reference
  Authors
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA.
  Title
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
  Journal
N Engl J Med 350:2129-39 (2004)
DOI:10.1056/NEJMoa040938
Reference
  Authors
Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M
  Title
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
  Journal
PLoS Med 2:e313 (2005)
DOI:10.1371/journal.pmed.0020313
Reference
  Authors
Yasuda H, Kobayashi S, Costa DB
  Title
EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.
  Journal
Lancet Oncol 13:e23-31 (2012)
DOI:10.1016/S1470-2045(11)70129-2
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