KEGG   DRUG: Lazertinib mesylate
Entry
D12245                      Drug                                   
Name
Lazertinib mesylate (USAN);
Lazertinib mesilate hydrate (JAN);
Lazcluze (TN)
Product
LAZCLUZE (Janssen Biotech)
Formula
C30H34N8O3. CH4SO3. H2O
Exact mass
668.2741
Mol weight
668.77
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03162  EGFR inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01EB09
Chemical structure group: DG03205
Product (DG03205): D12245<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Non-small cell lung cancer (EGFR exon 19 deletions or exon 21 (L858R) substitution mutated) [DS:H00014]
Target
EGFR* [HSA_VAR:1956v2] [HSA:1956] [KO:K04361]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
  Network
nt06266  Non-small cell lung cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EB Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
     L01EB09 Lazertinib
      D12245  Lazertinib mesylate (USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D12245  Lazertinib mesylate (USAN); Lazertinib mesilate hydrate (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03162  EGFR inhibitor
     DG03205  Lazertinib
      D12245  Lazertinib mesylate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03205  Lazertinib
     D12245  Lazertinib mesylate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR* [HSA_VAR:1956v2]
     D12245  Lazertinib mesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12245
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12245
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12245
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12245
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12245
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D12245
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03162  EGFR inhibitor
     DG03205  Lazertinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03205  Lazertinib
Other DBs
CAS: 2411549-88-5
PubChem: 497620658
LinkDB
KCF data

ATOM        47
            1   C8x C    20.2088  -20.1386
            2   C8y C    20.2088  -18.7353
            3   C8y C    21.4017  -18.0336
            4   C8x C    22.6647  -18.7353
            5   C8y C    22.6647  -20.1386
            6   C8y C    21.4017  -20.8403
            7   N1y N    23.8576  -20.8403
            8   N1b N    19.0159  -18.0336
            9   O2a O    21.4017  -16.6302
            10  C1x C    25.0504  -20.1386
            11  C1x C    26.3135  -20.8403
            12  O2x O    26.3135  -22.2437
            13  C1x C    25.1206  -22.9454
            14  C1x C    23.8576  -22.2437
            15  N1b N    21.4017  -22.2437
            16  C5a C    20.2088  -22.9454
            17  C2b C    19.0159  -22.2437
            18  O5a O    20.2088  -24.3488
            19  C2a C    17.8231  -22.9454
            20  C1a C    22.5945  -15.9285
            21  C8y C    19.0159  -16.6302
            22  N5x N    20.2088  -15.9285
            23  C8x C    20.2088  -14.5251
            24  C8x C    19.0159  -13.8234
            25  C8y C    17.8231  -14.5251
            26  N5x N    17.8231  -15.9285
            27  N4y N    16.6302  -13.8234
            28  N5x N    16.6302  -12.4201
            29  C8y C    15.2970  -11.9990
            30  C8y C    14.4550  -13.1217
            31  C8x C    15.2268  -14.2444
            32  C8y C    14.8760  -10.6658
            33  C8x C    15.7882   -9.6133
            34  C8x C    15.3671   -8.2801
            35  C8x C    14.0339   -7.9994
            36  C8x C    13.0516   -9.0520
            37  C8x C    13.4726  -10.3852
            38  C1b C    13.0516  -13.1217
            39  N1c N    12.3499  -14.3146
            40  C1a C    10.9465  -14.3146
            41  C1a C    13.0516  -15.5075
            42  S4a S    25.2700  -10.5700
            43  C1a C    23.8700  -10.5700
            44  O1d O    26.6700  -10.5700
            45  O1d O    25.2700   -9.1700
            46  O1d O    25.2700  -11.9700
            47  O0  O    27.0900  -14.3500
BOND        49
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     2   8 1
            9     3   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    7  14 1
            16    6  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 2
            20   17  19 2
            21    9  20 1
            22    8  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   25  27 1
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   27  31 1
            35   29  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   35  36 1
            40   36  37 2
            41   32  37 1
            42   30  38 1
            43   38  39 1
            44   39  40 1
            45   39  41 1
            46   42  43 1
            47   42  44 1
            48   42  45 2
            49   42  46 2

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