KEGG   DRUG: Remibrutinib
Entry
D12285                      Drug                                   
Name
Remibrutinib (JAN/USAN/INN);
Rhapsido (TN)
Product
RHAPSIDO (Novartis Pharmaceuticals Corporation)
Formula
C27H27F2N5O3
Exact mass
507.2082
Mol weight
507.53
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG02022  BTK inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: L04AA60
Product: D12285<US>
Efficacy
Autoimmune disease treatment, Bruton's tyrosine kinase inhibitor
Comment
Treatment of chronic spontaneous urticaria
Target
BTK [HSA:695] [KO:K07370]
  Pathway
hsa04064  NF-kappa B signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA60 Remibrutinib
      D12285  Remibrutinib (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG02022  BTK inhibitor
    D12285  Remibrutinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D12285  Remibrutinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Non-receptor tyrosine kinases
   TEC family
    BTK
     D12285  Remibrutinib (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12285
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12285
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12285
Other DBs
CAS: 1787294-07-8
PubChem: 497620698
LinkDB
KCF data

ATOM        37
            1   C8y C    10.9200  -14.7700
            2   C8y C    10.9200  -13.3700
            3   N5x N     9.7300  -12.6700
            4   C8x C     8.4700  -13.3700
            5   N5x N     8.4700  -14.7700
            6   C8y C     9.7300  -15.4700
            7   N1a N     9.7300  -16.8700
            8   O2a O    12.1100  -15.4700
            9   C1b C    12.1100  -16.8700
            10  C1b C    13.3000  -17.5700
            11  C8y C    12.1100  -12.6700
            12  C8y C    13.3000  -13.3700
            13  C8y C    14.5600  -12.6700
            14  C8x C    14.5600  -11.2700
            15  C8y C    13.3700  -10.5700
            16  C8x C    12.1100  -11.2700
            17  C1a C    13.3000  -14.7000
            18  X   F    13.3700   -9.1700
            19  N1b N    15.7500  -13.3700
            20  C5a C    16.9400  -12.6700
            21  C8y C    18.1300  -13.3700
            22  O5a O    16.9400  -11.2700
            23  C8x C    18.1300  -14.7700
            24  C8x C    19.3900  -15.4700
            25  C8y C    20.5800  -14.7700
            26  C8x C    20.5800  -13.3700
            27  C8y C    19.3900  -12.6700
            28  X   F    19.3900  -11.2700
            29  C1y C    21.7700  -15.4700
            30  C1x C    23.1700  -15.4700
            31  C1x C    22.4700  -16.6600
            32  N1c N    14.4900  -16.8700
            33  C5a C    15.6800  -17.5700
            34  C1a C    14.4900  -15.4700
            35  C2b C    16.8700  -16.8700
            36  O5a O    15.6800  -18.9700
            37  C2a C    18.0600  -17.5700
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     1   8 1
            9     8   9 1
            10    9  10 1
            11    2  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   12  17 1
            19   15  18 1
            20   13  19 1
            21   19  20 1
            22   20  21 1
            23   20  22 2
            24   21  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   21  27 1
            30   27  28 1
            31   25  29 1
            32   30  29 1
            33   29  31 1
            34   31  30 1
            35   10  32 1
            36   32  33 1
            37   32  34 1
            38   33  35 1
            39   33  36 2
            40   35  37 2

» Japanese version   » Back

DBGET integrated database retrieval system