Homo sapiens (human): 695
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Entry
695 CDS
T01001
Symbol
BTK, AGMX1, AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA
Name
(RefSeq) Bruton tyrosine kinase
KO
K07370
Bruton agammaglobulinemia tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04380
Osteoclast differentiation
hsa04611
Platelet activation
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa05169
Epstein-Barr virus infection
hsa05340
Primary immunodeficiency
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling (cancer)
nt06537
TCR/BCR signaling
Element
N00487
BCR-PLCG-Calcineurin signaling pathway
Disease
H00085
Agammaglobulinemias
H00254
Growth hormone deficiency
H02035
Isolated growth hormone deficiency
Drug target
Acalabrutinib (
DG03089
):
D10893
<JP/US>
D11720
D12704
<US>
Atuzabrutinib:
D12489
Bexobrutideg:
D13115
Branebrutinib:
D11478
Edralbrutinib:
D12383
Elsubrutinib:
D12158
Evobrutinib:
D12467
Fenebrutinib:
D11457
Ibrutinib:
D10223
<JP/US>
Luxeptinib:
D12052
Nemtabrutinib:
D12504
Orelabrutinib:
D12160
Pirtobrutinib:
D12050
<JP/US>
Remibrutinib:
D12285
Rilzabrutinib:
D11873
Spebrutinib (
DG01863
):
D10730
D10731
Tirabrutinib (
DG03266
):
D11070
<JP>
D12594
Tolebrutinib:
D12213
Vecabrutinib (
DG03023
):
D11428
D11502
Zanubrutinib:
D11422
<JP/US>
Zelebrudomide:
D12858
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
695 (BTK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
695 (BTK)
04662 B cell receptor signaling pathway
695 (BTK)
04664 Fc epsilon RI signaling pathway
695 (BTK)
09158 Development and regeneration
04380 Osteoclast differentiation
695 (BTK)
09160 Human Diseases
09172 Infectious disease: viral
05169 Epstein-Barr virus infection
695 (BTK)
09163 Immune disease
05340 Primary immunodeficiency
695 (BTK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
695 (BTK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
695 (BTK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
TEC family
695 (BTK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
PH
BTK
SH3_9
SH3_2
Kinase-like
SH3_10
SH3_3
ABC1
Pkinase_fungal
Kdo
Haspin_kinase
SH3_4
Motif
Other DBs
NCBI-GeneID:
695
NCBI-ProteinID:
NP_000052
OMIM:
300300
HGNC:
1133
Ensembl:
ENSG00000010671
UniProt:
Q06187
Q5JY90
Structure
PDB
PDBj
LinkDB
All DBs
Position
X:complement(101349450..101390796)
Genome browser
AA seq
659 aa
AA seq
DB search
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
NT seq
1980 nt
NT seq
+upstream
nt +downstream
nt
atggccgcagtgattctggagagcatctttctgaagcgatcccaacagaaaaagaaaaca
tcacctctaaacttcaagaagcgcctgtttctcttgaccgtgcacaaactctcctactat
gagtatgactttgaacgtgggagaagaggcagtaagaagggttcaatagatgttgagaag
atcacttgtgttgaaacagtggttcctgaaaaaaatcctcctccagaaagacagattccg
agaagaggtgaagagtccagtgaaatggagcaaatttcaatcattgaaaggttcccttat
cccttccaggttgtatatgatgaagggcctctctacgtcttctccccaactgaagaacta
aggaagcggtggattcaccagctcaaaaacgtaatccggtacaacagtgatctggttcag
aaatatcacccttgcttctggatcgatgggcagtatctctgctgctctcagacagccaaa
aatgctatgggctgccaaattttggagaacaggaatggaagcttaaaacctgggagttct
caccggaagacaaaaaagcctcttcccccaacgcctgaggaggaccagatcttgaaaaag
ccactaccgcctgagccagcagcagcaccagtctccacaagtgagctgaaaaaggttgtg
gccctttatgattacatgccaatgaatgcaaatgatctacagctgcggaagggtgatgaa
tattttatcttggaggaaagcaacttaccatggtggagagcacgagataaaaatgggcag
gaaggctacattcctagtaactatgtcactgaagcagaagactccatagaaatgtatgag
tggtattccaaacacatgactcggagtcaggctgagcaactgctaaagcaagaggggaaa
gaaggaggtttcattgtcagagactccagcaaagctggcaaatatacagtgtctgtgttt
gctaaatccacaggggaccctcaaggggtgatacgtcattatgttgtgtgttccacacct
cagagccagtattacctggctgagaagcaccttttcagcaccatccctgagctcattaac
taccatcagcacaactctgcaggactcatatccaggctcaaatatccagtgtctcaacaa
aacaagaatgcaccttccactgcaggcctgggatacggatcatgggaaattgatccaaag
gacctgaccttcttgaaggagctggggactggacaatttggggtagtgaagtatgggaaa
tggagaggccagtacgacgtggccatcaagatgatcaaagaaggctccatgtctgaagat
gaattcattgaagaagccaaagtcatgatgaatctttcccatgagaagctggtgcagttg
tatggcgtctgcaccaagcagcgccccatcttcatcatcactgagtacatggccaatggc
tgcctcctgaactacctgagggagatgcgccaccgcttccagactcagcagctgctagag
atgtgcaaggatgtctgtgaagccatggaatacctggagtcaaagcagttccttcaccga
gacctggcagctcgaaactgtttggtaaacgatcaaggagttgttaaagtatctgatttc
ggcctgtccaggtatgtcctggatgatgaatacacaagctcagtaggctccaaatttcca
gtccggtggtccccaccggaagtcctgatgtatagcaagttcagcagcaaatctgacatt
tgggcttttggggttttgatgtgggaaatttactccctggggaagatgccatatgagaga
tttactaacagtgagactgctgaacacattgcccaaggcctacgtctctacaggcctcat
ctggcttcagagaaggtatataccatcatgtacagttgctggcatgagaaagcagatgag
cgtcccactttcaaaattcttctgagcaatattctagatgtcatggatgaagaatcctga
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integrated database retrieval system
