Entry |
|
Name |
Codeine phosphate (USP); Codeine phosphate hydrate (JP18); Codeine (TN) |
Formula |
(C18H21NO3)2. 2H3PO4. H2O
|
Exact mass |
812.2686
|
Mol weight |
812.73
|
Structure |
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Simcomp |
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Class |
|
Remark |
Product (DG01076): | D02101<JP> D03580<US> |
Product (mixture): | D02146<US> D11851<US> D11852<US> D11860<US> D12138<US> D12312<US> |
|
Efficacy |
Analgesic (narcotic), Antitussive, Opioid receptor agonist |
Comment |
Opium alkaloid
Active form of prodrug: Morphine [DR: D08233]
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Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
Interaction |
|
Structure map |
map07224 | Opioid receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA04 Codeine
D02101 Codeine phosphate (USP) <JP>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Short-acting
Codeine
D02101 Codeine phosphate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
224 Antitussives and expectorants
2242 Codeines
D02101 Codeine phosphate (USP); Codeine phosphate hydrate (JP18)
8 Narcotics
81 Alkaloidal narcotics
811 Opium alkaloids
8115 Codeines
D02101 Codeine phosphate (USP); Codeine phosphate hydrate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
Agents for respiratory organs
26 Antitussives and expectorants
D02101 Codeine phosphate (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Codeine
D02101 Codeine phosphate (USP)
Second-class OTC drugs
Inorganic and organic chemicals
Codeine
D02101 Codeine phosphate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
D02101 Codeine phosphate
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
D02101 Codeine phosphate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
D02101 Codeine phosphate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
D02101 Codeine phosphate
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
D02101 Codeine phosphate
DG03190 UGT2B7 substrate
DG01076 Codeine
D02101 Codeine phosphate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D02101 Codeine phosphate (USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02101 Codeine phosphate hydrate
D02101 Codeine phosphate tablets
D02101 1% Codeine phosphate powder
D02101 10% Codeine phosphate powder
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02101
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
DG03190 UGT2B7 substrate
DG01076 Codeine
Prodrugs [br08324.html]
DG01076
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Other DBs |
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LinkDB |
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KCF data |
ATOM 55
1 O0 O 29.5066 -18.6348
2 C1z C 18.0622 -16.8904
3 C8y C 18.0622 -15.5648
4 C1y C 19.2482 -17.5881
5 C1y C 16.9458 -17.5183
6 C1x C 19.2482 -16.2625
7 C8y C 16.9458 -14.9368
8 C8y C 19.2482 -14.9368
9 C1y C 20.3645 -16.8904
10 C2x C 19.2482 -18.8439
11 O2x O 15.6202 -16.1927
12 C1y C 16.9458 -18.8439
13 C1x C 21.4808 -16.2625
14 C8y C 16.9458 -13.6112
15 C1x C 20.3645 -15.6345
16 C8x C 19.2482 -13.6112
17 N1y N 21.4808 -17.5881
18 C2x C 18.0622 -19.5416
19 O1a O 15.8295 -19.5416
20 C8x C 18.1319 -12.9833
21 O2a O 15.8295 -12.9833
22 C1a C 14.6435 -13.6112
23 C1a C 22.8808 -17.5881
24 P1b P 28.5285 -14.7289
25 O1c O 28.5285 -13.3335
26 O1c O 28.5285 -16.1243
27 O1c O 29.9238 -14.7289
28 O1c O 27.1331 -14.7289
29 C1z C 18.0622 -16.8904
30 C8y C 18.0622 -15.5648
31 C8y C 16.9458 -14.9368
32 C8y C 16.9458 -13.6112
33 C8x C 18.1319 -12.9833
34 C8x C 19.2482 -13.6112
35 C8y C 19.2482 -14.9368
36 C1x C 20.3645 -15.6345
37 C1y C 20.3645 -16.8904
38 C1y C 19.2482 -17.5881
39 C2x C 19.2482 -18.8439
40 C2x C 18.0622 -19.5416
41 C1y C 16.9458 -18.8439
42 C1y C 16.9458 -17.5183
43 O2x O 15.6202 -16.1927
44 O1a O 15.8295 -19.5416
45 N1y N 21.4808 -17.5881
46 C1x C 21.4808 -16.2625
47 C1x C 19.2482 -16.2625
48 C1a C 22.8808 -17.5881
49 O2a O 15.8295 -12.9833
50 C1a C 14.6435 -13.6112
51 P1b P 28.5285 -14.7289
52 O1c O 28.5285 -13.3335
53 O1c O 28.5285 -16.1243
54 O1c O 29.9238 -14.7289
55 O1c O 27.1331 -14.7289
BOND 60
1 2 3 1
2 2 4 1
3 2 5 1
4 2 6 1 #Up
5 3 7 2
6 3 8 1
7 4 9 1
8 4 10 1
9 5 11 1 #Down
10 5 12 1
11 6 13 1
12 7 14 1
13 8 15 1
14 8 16 2
15 9 17 1 #Up
16 10 18 2
17 12 19 1 #Down
18 14 20 2
19 14 21 1
20 21 22 1
21 7 11 1
22 9 15 1
23 12 18 1
24 13 17 1
25 16 20 1
26 17 23 1
27 29 30 1
28 29 38 1
29 29 42 1
30 29 47 1 #Up
31 30 31 2
32 30 35 1
33 38 37 1
34 38 39 1
35 42 43 1 #Down
36 42 41 1
37 47 46 1
38 31 32 1
39 35 36 1
40 35 34 2
41 37 45 1 #Up
42 39 40 2
43 41 44 1 #Down
44 32 33 2
45 32 49 1
46 49 50 1
47 31 43 1
48 37 36 1
49 41 40 1
50 46 45 1
51 34 33 1
52 45 48 1
53 24 25 2
54 24 26 1
55 24 27 1
56 24 28 1
57 51 52 2
58 51 53 1
59 51 54 1
60 51 55 1
BRACKET 1 12.7400 -20.3000 12.7400 -12.0400
1 24.3600 -12.0400 24.3600 -20.3000
1 2
ORIGINAL 1 2 3 7 14 20 16 8 15 9 4 10 18 12 5 11 19
1 23 17 13 6 24 21 22
REPEAT 1 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45
1 46 47 48 49 50 51 52
2 25.6900 -16.8000 25.6900 -12.6000
2 31.1500 -12.6000 31.1500 -16.8000
2 2
ORIGINAL 2 25 26 27 28 29
REPEAT 2 53 54 55 56 57
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