KEGG   DRUG: Tasurgratinib succinate
Entry
D12405                      Drug                                   
Name
Tasurgratinib succinate (JAN);
Tasfygo (TN)
Formula
(C32H37N5O6)2. (C4H6O4)3
Exact mass
1528.6286
Mol weight
1529.59
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03208  FGFR inhibitor
Remark
Therapeutic category: 4291
Chemical structure group: DG03234
Product (DG03234): D12405<JP>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
FGFR2* (CD332) [HSA_VAR:2263v2] [HSA:2263] [KO:K05093]
FGFR1 (CD331) [HSA:2260] [KO:K04362]
FGFR3 (CD333) [HSA:2261] [KO:K05094]
  Pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D12405  Tasurgratinib succinate (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     DG03234  Tasurgratinib
      D12405  Tasurgratinib succinate
    DG03234  Tasurgratinib
     D12405  Tasurgratinib succinate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR1 (CD331)
     D12405  Tasurgratinib succinate (JAN) <JP>
    FGFR2* (CD332) [HSA_VAR:2263v2]
     D12405  Tasurgratinib succinate (JAN) <JP>
    FGFR3 (CD333)
     D12405  Tasurgratinib succinate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12405
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12405
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     DG03234  Tasurgratinib
    DG03234  Tasurgratinib
Other DBs
CAS: 1879965-80-6
PubChem: 497620818
LinkDB
KCF data

ATOM        110
            1   N1y N    13.7462  -18.8041
            2   C1x C    13.7462  -17.3307
            3   C1x C    15.0091  -16.6290
            4   C1y C    16.2019  -17.3307
            5   C1x C    16.2019  -18.8041
            6   C1x C    15.0091  -19.5057
            7   C1b C    12.5534  -19.5057
            8   C1b C    11.3606  -18.8041
            9   C8y C    17.3947  -16.6290
            10  C8x C    17.3947  -15.2258
            11  C8x C    18.5875  -14.5241
            12  C8y C    19.7803  -15.2258
            13  C8x C    19.7803  -16.6290
            14  C8x C    18.5875  -17.3307
            15  C5a C    21.0432  -14.5241
            16  O1a O    10.0977  -19.5057
            17  O5a O    21.1134  -13.1910
            18  N1b N    22.3062  -15.2959
            19  C8y C    22.3062  -16.6992
            20  N5x N    21.0432  -17.4008
            21  C8x C    21.0432  -18.8041
            22  C8x C    22.3062  -19.5057
            23  C8y C    23.4990  -18.8041
            24  C8x C    23.4990  -17.4008
            25  O2a O    24.6918  -19.4356
            26  C8y C    25.8846  -18.7339
            27  C8x C    27.0774  -19.4356
            28  C8y C    28.2702  -18.7339
            29  C8y C    28.2702  -17.3307
            30  C8x C    27.0774  -16.6992
            31  C8y C    25.8846  -17.4008
            32  O2a O    24.6217  -16.6290
            33  C1b C    24.6217  -15.2258
            34  C1b C    25.8144  -14.5241
            35  C8x C    29.6033  -19.1549
            36  C8x C    30.4452  -18.0323
            37  N4y N    29.6033  -16.9097
            38  C5a C    30.0242  -15.5766
            39  N1b N    31.4275  -15.2959
            40  O5a O    29.1121  -14.5943
            41  C1a C    32.3396  -16.3484
            42  O2a O    25.8144  -13.1208
            43  C1a C    27.0072  -12.4192
            44  C6a C    39.1608  -16.8154
            45  C1b C    40.3743  -17.5160
            46  O6a O    37.9473  -17.5160
            47  O6a O    39.1608  -15.4141
            48  C1b C    41.5709  -16.8250
            49  C6a C    42.7594  -17.5111
            50  O6a O    43.9517  -16.8225
            51  O6a O    42.7596  -18.9171
            52  N1y N    13.7462  -18.8041
            53  C1x C    13.7462  -17.3307
            54  C1x C    15.0091  -16.6290
            55  C1y C    16.2019  -17.3307
            56  C1x C    16.2019  -18.8041
            57  C1x C    15.0091  -19.5057
            58  C8y C    17.3947  -16.6290
            59  C8x C    17.3947  -15.2258
            60  C8x C    18.5875  -14.5241
            61  C8y C    19.7803  -15.2258
            62  C8x C    19.7803  -16.6290
            63  C8x C    18.5875  -17.3307
            64  C5a C    21.0432  -14.5241
            65  O5a O    21.1134  -13.1910
            66  N1b N    22.3062  -15.2959
            67  C8y C    22.3062  -16.6992
            68  N5x N    21.0432  -17.4008
            69  C8x C    21.0432  -18.8041
            70  C8x C    22.3062  -19.5057
            71  C8y C    23.4990  -18.8041
            72  C8x C    23.4990  -17.4008
            73  O2a O    24.6918  -19.4356
            74  C8y C    25.8846  -18.7339
            75  C8x C    27.0774  -19.4356
            76  C8y C    28.2702  -18.7339
            77  C8y C    28.2702  -17.3307
            78  C8x C    27.0774  -16.6992
            79  C8y C    25.8846  -17.4008
            80  O2a O    24.6217  -16.6290
            81  C1b C    24.6217  -15.2258
            82  C1b C    25.8144  -14.5241
            83  O2a O    25.8144  -13.1208
            84  C1a C    27.0072  -12.4192
            85  N4y N    29.6033  -16.9097
            86  C8x C    30.4452  -18.0323
            87  C8x C    29.6033  -19.1549
            88  C5a C    30.0242  -15.5766
            89  N1b N    31.4275  -15.2959
            90  C1a C    32.3396  -16.3484
            91  O5a O    29.1121  -14.5943
            92  C1b C    12.5534  -19.5057
            93  C1b C    11.3606  -18.8041
            94  O1a O    10.0977  -19.5057
            95  C6a C    39.1608  -16.8154
            96  C1b C    40.3743  -17.5160
            97  C1b C    41.5709  -16.8250
            98  C6a C    42.7594  -17.5111
            99  O6a O    43.9517  -16.8225
            100 O6a O    42.7596  -18.9171
            101 O6a O    37.9473  -17.5160
            102 O6a O    39.1608  -15.4141
            103 C6a C    39.1608  -16.8154
            104 C1b C    40.3743  -17.5160
            105 C1b C    41.5709  -16.8250
            106 C6a C    42.7594  -17.5111
            107 O6a O    43.9517  -16.8225
            108 O6a O    42.7596  -18.9171
            109 O6a O    37.9473  -17.5160
            110 O6a O    39.1608  -15.4141
BOND        115
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   12  15 1
            17    8  16 1
            18   15  17 2
            19   15  18 1
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   23  25 1
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   26  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   28  35 1
            39   35  36 2
            40   36  37 1
            41   29  37 1
            42   37  38 1
            43   38  39 1
            44   38  40 2
            45   39  41 1
            46   34  42 1
            47   42  43 1
            48   52  53 1
            49   53  54 1
            50   54  55 1
            51   55  56 1
            52   56  57 1
            53   52  57 1
            54   52  92 1
            55   92  93 1
            56   55  58 1
            57   58  59 2
            58   59  60 1
            59   60  61 2
            60   61  62 1
            61   62  63 2
            62   58  63 1
            63   61  64 1
            64   93  94 1
            65   64  65 2
            66   64  66 1
            67   66  67 1
            68   67  68 2
            69   68  69 1
            70   69  70 2
            71   70  71 1
            72   71  72 2
            73   67  72 1
            74   71  73 1
            75   73  74 1
            76   74  75 2
            77   75  76 1
            78   76  77 2
            79   77  78 1
            80   78  79 2
            81   74  79 1
            82   79  80 1
            83   80  81 1
            84   81  82 1
            85   76  87 1
            86   87  86 2
            87   86  85 1
            88   77  85 1
            89   85  88 1
            90   88  89 1
            91   88  91 2
            92   89  90 1
            93   82  83 1
            94   83  84 1
            95   44  45 1
            96   44  46 1
            97   44  47 2
            98   45  48 1
            99   48  49 1
            100  49  50 1
            101  49  51 2
            102  95  96 1
            103  95 101 1
            104  95 102 2
            105  96  97 1
            106  97  98 1
            107  98  99 1
            108  98 100 2
            109 103 104 1
            110 103 109 1
            111 103 110 2
            112 104 105 1
            113 105 106 1
            114 106 107 1
            115 106 108 2
BRACKET     1     8.4000  -20.7900    8.4000  -11.4100
            1    34.3000  -11.4100   34.3000  -20.7900
            1  2
 ORIGINAL  1    1   2   3   4   5   6   9  10  11  12  13  14  15  17  18  19
            1   20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  42
            1   43  37  36  35  38  39  41  40   7   8  16
 REPEAT    1   52  53  54  55  56  57  58  59  60  61  62  63  64  65  66  67
            1   68  69  70  71  72  73  74  75  76  77  78  79  80  81  82  83
            1   84  85  86  87  88  89  90  91  92  93  94
            2    36.4700  -19.6000   36.4700  -14.2800
            2    45.2900  -14.2800   45.2900  -19.6000
            2  3
 ORIGINAL  2   44  45  48  49  50  51  46  47
 REPEAT    2   95  96  97  98  99 100 101 102 103 104 105 106 107 108 109 110

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