KEGG   DRUG: Sunvozertinib
Entry
D12506                      Drug                                   
Name
Sunvozertinib (USAN/INN);
Zegfrovy (TN)
Formula
C29H35ClFN7O3
Exact mass
583.2474
Mol weight
584.08
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03162  EGFR inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Non-small cell lung cancer (EGFR exon 20 insertion mutation) [DS:H00014]
Comment
Treatment of non-small cell lung cancer
Target
EGFR* [HSA_VAR:1956v2] [HSA:1956] [KO:K04361]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
  Network
nt06266  Non-small cell lung cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03162  EGFR inhibitor
     D12506  Sunvozertinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D12506  Sunvozertinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR* [HSA_VAR:1956v2]
     D12506  Sunvozertinib (USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12506
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12506
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12506
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D12506
Other DBs
CAS: 2370013-12-8
PubChem: 497620919
LinkDB
KCF data

ATOM        41
            1   C8y C    20.7991  -20.5153
            2   N5x N    20.7991  -21.9157
            3   C8y C    21.9894  -22.6159
            4   N5x N    23.2498  -21.9157
            5   C8x C    23.2498  -20.5153
            6   C8x C    21.9894  -19.8151
            7   N1b N    21.9722  -24.0162
            8   C8y C    23.1889  -24.7389
            9   C8x C    23.1718  -26.1169
            10  C8y C    24.3758  -26.8321
            11  C8y C    25.5972  -26.1471
            12  C8x C    25.6143  -24.7691
            13  C8y C    24.4104  -24.0538
            14  N1b N    19.5834  -19.8200
            15  C8y C    18.3947  -20.5130
            16  C8y C    17.1980  -19.8286
            17  C8x C    15.9880  -20.5337
            18  C8y C    15.9937  -21.9341
            19  C8y C    17.1904  -22.6185
            20  C8x C    18.4003  -21.9134
            21  X   F    14.7728  -22.6459
            22  C1d C    17.1920  -18.4152
            23  O1a O    17.1920  -17.0148
            24  C1a C    15.8616  -18.4152
            25  C1a C    18.6624  -18.4152
            26  X   Cl   17.1959  -24.0158
            27  O2a O    24.4281  -22.6860
            28  C1a C    25.6589  -21.9964
            29  N1b N    24.3585  -28.2175
            30  C5a C    23.1458  -28.8975
            31  O5a O    23.1977  -30.3171
            32  N1y N    26.8117  -26.8690
            33  C1x C    26.9420  -28.2822
            34  C1y C    28.3263  -28.5951
            35  C1x C    29.0516  -27.3751
            36  C1x C    28.1155  -26.3084
            37  N1c N    28.8750  -29.8703
            38  C1a C    30.2453  -30.0322
            39  C1a C    28.0159  -31.0219
            40  C2b C    21.9591  -28.2313
            41  C2a C    20.7834  -28.9292
BOND        44
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   18  21 1
            24   16  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1
            28   19  26 1
            29   13  27 1
            30   27  28 1
            31   10  29 1
            32   29  30 1
            33   30  31 2
            34   11  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   35  36 1
            39   32  36 1
            40   34  37 1 #Up
            41   37  38 1
            42   37  39 1
            43   30  40 1
            44   40  41 2

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