KEGG GLYCAN: G00109

GLYCAN: G00109

Entry

G00109 Glycan

Name

GM2;
Ganglioside

Composition

(Gal)1 (GalNAc)1 (Glc)1 (Neu5Ac)1 (Cer)1

Mass

818.7 (Cer)

Structure

Remark

Same as:

C04884

Reaction

R05939 R05941 R06004 R06007 R06009 R06010 R06012

Pathway

map00604

Glycosphingolipid biosynthesis - ganglio series

map01100

Metabolic pathways

Enzyme

2.4.1.62 2.4.1.92 2.4.99.8 2.4.99.9
3.2.1.18 3.2.1.23 3.2.1.52

Orthology

K00715

ganglioside galactosyltransferase [EC:2.4.1.62]

K00725

(N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase [EC:2.4.1.92]

Brite

Compounds with biological roles [BR:br08001]
Lipids
  Glycolipids
   Glycosphingolipids
    C04884  GM2
Lipids [BR:br08002]
SP  Sphingolipids
  SP06 Acidic glycosphingolipids
   SP0601 Gangliosides
    G00109  GalNAc-beta1->4(Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer (GM2)
Cancer-associated carbohydrates [br08441.html]
G00109

Reference

1 [PMID:15546874]

Authors

Ideo H, Seko A, Yamashita K.

Title

Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells.

Journal

J Biol Chem 280:4730-7 (2005)
DOI:10.1074/jbc.M410362200

Other DBs

CCSD:

633 634 2262 2553 3593 5156 5659 6838 6883 7530 7874 8106 8139 8272 9319 9912 9984 10292 10991 11324 11388 11570 13635 14441 14490 14564 14866 16222 16366 16536 17021 17089 17099 17690 17744 18831 18916 18922 18924 18928 18938 18948 19180 19361 19363 20309 20351 20357 20464 20956 20986 21349 21510 21711 21808 22056 22085 22203 22218 22661 23029 23662 23840 23859 23869 23887 23909 23942 24238 24645 24774 24961 24992 25135 25281 25355 25409 25447 25526 25541 25551 25586 25914 25923 25941 25946 25957 25984 26015 26026 26142 26274 26740 26750 26923 27236 27243 27254 27327 27388 27468 27671 28547 28566 28588 28795 29149 29474 29952 29961 29994 30640 30645 30897 30927 32036 32065 32083 32103 32557 32584 32676 32683 32703 32746 32755 32763 32788 32895 33346 33636 33650 33679 33943 34658 34669 34682 34690 34696 34748 34812 34820 34858 34887 34894 34902 34907 34929 34933 35034 35155 35297 35310 35319 35337 35354 35361 35366 35385 35405 35410 35420 35433 35475 35521 35541 35554 35566 35574 35586 35602 35608 35628 35657 35707 35788 35799 35830 35928 35998 36108 36143 36175 36347 36386 36658 36821 36865 36889 36896 36902 36928 36978 37022 37057 37218 37256 37278 37340 37617 37639 38078 38082 38115 38332 38380 38407 38631 39201 39372 39388 39430 40327 40450 40731 40748 41008 41102 41190 41884 42045 42141 42580 42734 42958 43026 43430 43432 43463 43573 44043 44070 44087 44222 44425 44500 44544 44807 44883 44940 44963 45134 45142 45156 45294 45311 45357 45721 45857 46032 46035 46059 46176 46263 46446 46523 46524 46525 46527 46563 46842 46864 46922 46987 47176 47329 47332 47376 47394 47407 47428 47699 47851 48210 48354 48365 48378 48381 48413 48417 48422 48519 48536 48899 48905 48927 49455 49499 50138 50146 50158 50189 50207 50211 50259 50263 50699 50794

GlyTouCan:

JCGGDB:

LipidBank:

GlycoEpitope:

LinkDB

KCF data

NODE        5
            1   Cer        13     0
            2   Glc         5     0
            3   Gal        -3     0
            4   GalNAc    -14     4
            5   Neu5Ac    -14    -4
EDGE        4
            1     2:b1    1:1
            2     3:b1    2:4
            3     4:b1    3:4
            4     5:a2    3:3

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