KEGG   DISEASE: Poor drug metabolism
エントリ  
H01171                                                             
名称    
Poor drug metabolism
概要    
Many administered drugs are first activated by phase I drug-metabolizing enzymes, such as cytochrome P450 (CYP). There are some defective activity mutants due to CYP polymorphisms. In these cases, drugs are not metabolized, the high drug levels in blood are maintained, and toxic effects appear in the patients.
カテゴリ  
先天性代謝異常症
パスウェイ 
hsa00982  Drug metabolism - cytochrome P450
病因遺伝子 
CYP2C19 [HSA:1557] [KO:K17721]
CYP2D6 [HSA:1565] [KO:K17712]
コメント  
In Caucasians and Asians, PM and allele frequency levels of CYPs (CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) are summarized from previous findings.
リンク   
MeSH: C563703 C563835
OMIM: 609535 608902
文献    
PMID:12959412
  著者
Mizutani T
  タイトル
PM frequencies of major CYPs in Asians and Caucasians.
  雑誌
Drug Metab Rev 35:99-106 (2003)
DOI:10.1081/DMR-120023681
文献    
PMID:12879168
  著者
Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, Brockmoller J, Frotschl R, Kopke K, Gerloff T, Chernov JN, Roots I
  タイトル
Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.
  雑誌
Eur J Clin Pharmacol 59:303-12 (2003)
DOI:10.1007/s00228-003-0606-2
文献    
PMID:9093256
  著者
Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T
  タイトル
High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.
  雑誌
Lancet 349:921-2 (1997)
DOI:10.1016/S0140-6736(05)62696-7
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