KEGG   DISEASE: Microvascular complications of diabetes
Entry
H02559                      Disease                                
Name
Microvascular complications of diabetes
  Subgroup
Diabetic nephropathy [DS:H01456]
Diabetic retinopathy [DS:H01457]
Diabetic neuropathy [DS:H01459]
Description
Microvascular complications of diabetes (MVCD) caused by damage in the small blood vessels contribute to pathologic and functional changes in many tissues, including eye, heart, kidney, skin, and neuronal tissues. These changes are traditionally known as diabetic retinopathy, nephropathy, and neuropathy.
Category
Endocrine and metabolic disease
Brite
Human diseases [BR:br08402]
 Endocrine and metabolic diseases
  Diabetes
   H02559  Microvascular complications of diabetes
Human diseases in ICD-11 classification [BR:br08403]
 08 Diseases of the nervous system
  Disorders of nerve root, plexus or peripheral nerves
   Polyneuropathy
    8C03  Other secondary polyneuropathy
     H02559  Microvascular complications of diabetes
 09 Diseases of the visual system
  Disorders of the eyeball posterior segment
   Disorders of the retina
    9B71  Retinopathy
     H02559  Microvascular complications of diabetes
 16 Diseases of the genitourinary system
  Diseases of the urinary system
   Kidney failure
    GB61  Chronic kidney disease
     H02559  Microvascular complications of diabetes
Gene
(MVCD1) VEGFA [HSA:7422] [KO:K05448]
(MVCD2) EPO [HSA:2056] [KO:K05437]
(MVCD3) ACE [HSA:1636] [KO:K01283]
(MVCD4) IL1RN [HSA:3557] [KO:K05481]
(MVCD5) PON1 [HSA:5444] [KO:K01045]
(MVCD6) SOD2 [HSA:6648] [KO:K04564]
(MVCD7) HFE [HSA:3077]
Other DBs
ICD-11: GB61.Z 9B71.0 8C03.0
ICD-10: E14.2 E14.3 E14.4
MeSH: D003928 D003930 D003929
OMIM: 603933 612623 612624 612628 612633 612634 612635
Reference
  Authors
He Z, King GL
  Title
Microvascular complications of diabetes.
  Journal
Endocrinol Metab Clin North Am 33:215-38, xi-xii (2004)
DOI:10.1016/j.ecl.2003.12.003
Reference
  Authors
Li J, Cao Y, Liu W, Wang Q, Qian Y, Lu P
  Title
Correlations among Diabetic Microvascular Complications: A Systematic Review and Meta-analysis.
  Journal
Sci Rep 9:3137 (2019)
DOI:10.1038/s41598-019-40049-z
Reference
PMID:11978667 (MVCD1)
  Authors
Awata T, Inoue K, Kurihara S, Ohkubo T, Watanabe M, Inukai K, Inoue I, Katayama S
  Title
A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.
  Journal
Diabetes 51:1635-9 (2002)
DOI:10.2337/diabetes.51.5.1635
Reference
PMID:18458324 (MVCD2)
  Authors
Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K
  Title
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.
  Journal
Proc Natl Acad Sci U S A 105:6998-7003 (2008)
DOI:10.1073/pnas.0800454105
Reference
PMID:9120002 (MVCD3)
  Authors
Marre M, Jeunemaitre X, Gallois Y, Rodier M, Chatellier G, Sert C, Dusselier L, Kahal Z, Chaillous L, Halimi S, Muller A, Sackmann H, Bauduceau B, Bled F, Passa P, Alhenc-Gelas F
  Title
Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group.
  Journal
J Clin Invest 99:1585-95 (1997)
DOI:10.1172/JCI119321
Reference
PMID:8786086 (MVCD4)
  Authors
Blakemore AI, Cox A, Gonzalez AM, Maskil JK, Hughes ME, Wilson RM, Ward JD, Duff GW
  Title
Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus.
  Journal
Hum Genet 97:369-74 (1996)
DOI:10.1007/BF02185776
Reference
PMID:9661650 (MVCD5)
  Authors
Kao YL, Donaghue K, Chan A, Knight J, Silink M
  Title
A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM.
  Journal
J Clin Endocrinol Metab 83:2589-92 (1998)
DOI:10.1210/jcem.83.7.5096
Reference
PMID:12624725 (MVCD6)
  Authors
Nomiyama T, Tanaka Y, Piao L, Nagasaka K, Sakai K, Ogihara T, Nakajima K, Watada H, Kawamori R
  Title
The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.
  Journal
J Hum Genet 48:138-41 (2003)
DOI:10.1007/s100380300021
Reference
PMID:14618419 (MVCD7)
  Authors
Peterlin B, Globocnik Petrovic M, Makuc J, Hawlina M, Petrovic D
  Title
A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
  Journal
J Hum Genet 48:646-649 (2003)
DOI:10.1007/s10038-003-0094-3
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