KEGG   DISEASE: Neurosis
Entry
H01671                      Disease                                
Name
Neurosis;
Neurotic disorder
Description
Neurosis is a class of functional mental disorders involving distress but neither delusions nor hallucinations, whereby behavior is not outside socially acceptable norms. The state of research on neurosis has moved towards looking at biological and genetic substrates or mechanisms underlying neurosis. The recent literature shows acceptance of common mental disorders such as Generalized anxiety disorder (GAD), Panic disorder (PD), and Obsessive-compulsive disorder (OCD), across cultures replacing neurotic disorder. Usage of the diagnosis of neurosis has been decreased, and replaced by newer categories in the current popular classificatory systems. In the International Classification of Diseases (ICD-10), all disorders regarded as neurosis remained together but under the division of rubric 'neurotic, stress-related and somatoform disorders'. In the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), neurosis has been eliminated as a category.
Category
Mental and behavioural disorder
Brite
Human diseases [BR:br08402]
 Other diseases
  Mental and behavioural disorders
   H01671  Neurosis
Related
pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Gene
DRD4 (polymorphism) [HSA:1815] [KO:K04147]
Comment
See also H01662 Generalized anxiety disorder, H01664 Panic disorder, H01670 Social anxiety disorder, and H01453 Obsessive-Compulsive and Related Disorder (OCRD).
Other DBs
ICD-10: F48
MeSH: D009497
Reference
  Authors
Chaturvedi SK, Bhugra D
  Title
The concept of neurosis in a cross-cultural perspective.
  Journal
Curr Opin Psychiatry 20:47-51 (2007)
DOI:10.1097/YCO.0b013e328010ca65
Reference
  Authors
Tochigi M, Hibino H, Otowa T, Kato C, Marui T, Ohtani T, Umekage T, Kato N, Sasaki T
  Title
Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population.
  Journal
Neurosci Lett 398:333-6 (2006)
DOI:10.1016/j.neulet.2006.01.020
LinkDB

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