KEGG   DISEASE: Optic neuritis
H01717                      Disease                                
Optic neuritis
Optic neuritis is a demyelinating inflammatory disease of the optic nerve that presents with an abrupt loss of vision. The majority of patients are between the ages of 20 and 50 years, with a mean age ranging from 30 to 35 years. It occurs more commonly in women than in men. The onset is usually with pain on eye movement in one eye and subacute visual loss. One-third of patients have a mildly edematous optic disc. The visual disturbance resolves in 95% of cases. Many cases of optic neuritis are associated with multiple sclerosis or neuromyelitis optica or can occur in isolation. Occasionally, optic neuritis can result from infectious processes involving the paranasal sinuses or occur in the course of a systemic viral infection. High-dosed intravenous methylprednisolone therapy speeds recovery but does not improve the final outcome. For patients judged to be at high risk of developing multiple sclerosis, immune prophylaxis with beta-interferon or glatiramer acetate is recommended.
Nervous system disease
Human diseases [BR:br08402]
 Nervous system diseases
  Eye disease
   H01717  Optic neuritis
Human diseases in ICD-11 classification [BR:br08403]
 09 Diseases of the visual system
  Disorders of the visual pathways or centres
   9C40  Disorder of the optic nerve
    H01717  Optic neuritis
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Prednisolone [DR:D00472]
Methylprednisolone [DR:D00407]
Corticotropin [DR:D00146]
Cortisone acetate [DR:D00973]
See also H01490 Multiple sclerosis and H01491 Neuromyelitis optica.
Other DBs
ICD-11: 9C40.1
ICD-10: H46
MeSH: D009902
Pedro-Egbe CN, Fiebai B, Ejimadu CS
Visual outcome following optic neuritis: a 5-year review.
Niger J Clin Pract 15:311-4 (2012)
Gal RL, Vedula SS, Beck R
Corticosteroids for treating optic neuritis.
Cochrane Database Syst Rev CD001430 (2015)
Wilhelm H, Schabet M
The Diagnosis and Treatment of Optic Neuritis.
Dtsch Arztebl Int 112:616-25; quiz 626 (2015)

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