KEGG   DISEASE: Coronary artery disease
Entry
H01742                      Disease                                
Name
Coronary artery disease
Description
Coronary artery disease (CAD) is one of the leading causes of death globally. CAD is coupled to a pathogenic process in which lipids and lipoproteins accumulate in the subendothelial intimal layer of the vessel wall. A variety of environmental and genetic risk factors are associated with CAD, including hypercholesterolemia, hypertension, obesity, diabetes, and a family history of early CAD. It has been reported that an autosomal dominant form of CAD is caused by the mutation in transcription factor MEF2A. A missense mutation in LRP6, which encodes a co-receptor in the Wnt signaling pathway, has also been identified.
Category
Vascular disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Vascular diseases
   H01742  Coronary artery disease
Human diseases in ICD-11 classification [BR:br08403]
 11 Diseases of the circulatory system
  Diseases of coronary artery
   BA80  Coronary atherosclerosis
    H01742  Coronary artery disease
Pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04022  cGMP-PKG signaling pathway
hsa04310  Wnt signaling pathway
Gene
(ADCAD1) MEF2A [HSA:4205] [KO:K09260]
(ADCAD2) LRP6 [HSA:4040] [KO:K03068]
(CHDS1) CX3CR1 [HSA:1524] [KO:K04192]
(CHDS5) KALRN [HSA:8997] [KO:K15048]
(CHDS6) MMP3 [HSA:4314] [KO:K01394]
(CHDS7) CD36 [HSA:948] [KO:K06259]
Drug
Nitroglycerin [DR:D00515]
Niacin [DR:D00049]
Amlodipine benzoate [DR:D11881]
Perindopril erbumine [DR:D00624]
Amlodipine besilate and atorvastatin calcium [DR:D08488]
Other DBs
ICD-11: BA80
ICD-10: I25.1
MeSH: D003324
OMIM: 608320 610947 607339 608901 614466 610938
Reference
  Authors
Olson EN
  Title
Coronary artery disease and the MEF2A transcription factor.
  Journal
Sci Aging Knowledge Environ 2003:pe33 (2003)
DOI:10.1126/sageke.2003.48.pe33
Reference
  Authors
Grover MP, Ballouz S, Mohanasundaram KA, George RA, Goscinski A, Crowley TM, Sherman CD, Wouters MA
  Title
Novel therapeutics for coronary artery disease from genome-wide association study data.
  Journal
BMC Med Genomics 8 Suppl 2:S1 (2015)
DOI:10.1186/1755-8794-8-S2-S1
Reference
PMID:14645853 (MEF2A)
  Authors
Wang L, Fan C, Topol SE, Topol EJ, Wang Q
  Title
Mutation of MEF2A in an inherited disorder with features of coronary artery disease.
  Journal
Science 302:1578-81 (2003)
DOI:10.1126/science.1088477
Reference
PMID:17332414 (LRP6)
  Authors
Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP
  Title
LRP6 mutation in a family with early coronary disease and metabolic risk factors.
  Journal
Science 315:1278-82 (2007)
DOI:10.1126/science.1136370
Reference
PMID:11264153 (CX3CR1)
  Authors
Moatti D, Faure S, Fumeron F, Amara Mel-W, Seknadji P, McDermott DH, Debre P, Aumont MC, Murphy PM, de Prost D, Combadiere C
  Title
Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.
  Journal
Blood 97:1925-8 (2001)
DOI:10.1182/blood.v97.7.1925
Reference
PMID:17357071 (KALRN)
  Authors
Wang L, Hauser ER, Shah SH, Pericak-Vance MA, Haynes C, Crosslin D, Harris M, Nelson S, Hale AB, Granger CB, Haines JL, Jones CJ, Crossman D, Seo D, Gregory SG, Kraus WE, Goldschmidt-Clermont PJ, Vance JM
  Title
Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.
  Journal
Am J Hum Genet 80:650-63 (2007)
DOI:10.1086/512981
Reference
PMID:8662692 (MMP3)
  Authors
Ye S, Eriksson P, Hamsten A, Kurkinen M, Humphries SE, Henney AM
  Title
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.
  Journal
J Biol Chem 271:13055-60 (1996)
DOI:10.1074/jbc.271.22.13055
Reference
PMID:15282206 (CD36)
  Authors
Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, Iori E, Lager RA, Shroff AR, Gervino EV, Nesto RW, Johnstone MT, Abumrad NA, Avogaro A, Trischitta V, Doria A
  Title
A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians.
  Journal
Hum Mol Genet 13:2197-205 (2004)
DOI:10.1093/hmg/ddh233
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