Homo sapiens (human): 8997
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Entry
8997 CDS
T01001
Symbol
KALRN, ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, KALNC2, TRAD
Name
(RefSeq) kalirin RhoGEF kinase
KO
K15048
kalirin [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Disease
H01742
Coronary artery disease
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
8997 (KALRN)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
8997 (KALRN)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
8997 (KALRN)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
8997 (KALRN)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CAMK group
Trio family [OT]
8997 (KALRN)
Membrane trafficking [BR:
hsa04131
]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
8997 (KALRN)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
8997 (KALRN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RhoGEF
SOS1_NGEF_PH
Pkinase
Spectrin_6
SH3_KALRN
Spectrin
SH3-RhoG_link
PK_Tyr_Ser-Thr
I-set
PH
Ig_3
fn3
CRAL_TRIO_2
ig
Ig_DSCAM-DSCAML_C
Spectrin_SESTD1
IQ_SEC7_PH
PH_10
SH3_2
SH3_1
PH_19
CRAL_TRIO
Ig_2
PH_13
SH3_9
DUF7799
V-set
Pur_ac_phosph_N
RL11D
T4_Rnl2_C
Motif
Other DBs
NCBI-GeneID:
8997
NCBI-ProteinID:
NP_001019831
OMIM:
604605
HGNC:
4814
Ensembl:
ENSG00000160145
UniProt:
O60229
Structure
PDB
PDBj
LinkDB
All DBs
Position
3:124033369..124726325
Genome browser
AA seq
2986 aa
AA seq
DB search
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF
PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP
AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH
EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA
PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH
VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN
SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF
HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD
VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV
FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL
QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE
ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE
VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT
EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK
QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ
QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE
SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI
HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK
QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE
KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP
DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK
DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL
FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL
KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD
GSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPS
ERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSE
SVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSF
DLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLL
AARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEE
EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIH
QIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFE
EVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR
CNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL
RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQD
INQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGS
SYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEI
CVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKS
CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI
LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT
YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER
SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF
RVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK
CIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELM
DDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRV
KLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQP
HNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT
NT seq
8961 nt
NT seq
+upstream
nt +downstream
nt
atgacggaccgcttctgggaccagtggtatctctggtatctccgcttgctccggctgctg
gatcgagggtcttttcggaatgatggtttgaaagcttctgatgtccttcctatcctaaag
gaaaaggtggccttcgtgtctgggggtcgtgataagcgaggcggacccatcctgaccttc
cctgctcgcagcaatcatgacagaataagacaggaagacctgcggaaactcgtgacgtat
ttggccagcgtgccaagtgaggacgtgtgcaaacgtggcttcactgtcatcatcgacatg
cggggctccaagtgggacctcatcaagcccctcctcaaaacgctgcaggaagcctttcca
gctgagatccatgtggccctcatcattaaacccgacaacttctggcagaaacagaagacc
aactttggcagctccaaattcatctttgagacgagcatggtatctgtggagggcctcaca
aagctggtggacccctcccagctgacggaggagtttgatggctccctggactacaaccat
gaggagtggatcgaactgcggctctccctggaggagttcttcaacagcgccgtgcacctg
ctctcgcgcctcgaggacctccaggagatgctagcccggaaggagtttcctgtggatgtg
gagggctctcggcggctcattgacgaacacacacagctcaagaaaaaggtgctgaaggcc
cctgtggaggagctggaccgggaggggcagcggctgctgcagtgcatccgctgcagcgac
ggcttctcaggacgcaactgcatcccgggcagtgctgacttccagagcctggtgcccaag
atcaccagtctcctggacaagctgcactccacccggcagcacctgcaccagatgtggcat
gtgcgcaagctcaagctggaccagtgctttcagctgcggctcttcgagcaggatgctgag
aagatgtttgactggataagccacaacaaggagttattcctccagagccacacggagatc
ggagtcagctaccagtacgcccttgacctccagacgcagcacaatcactttgccatgaac
tccatgaatgcctatgtcaacatcaaccgcatcatgtccgtggcttcccgcctctctgag
gccggtcattatgcctcacaacaaatcaagcagatctccacccagctggaccaggagtgg
aagagcttcgctgctgccctggatgaacgcagcaccatcctcgccatgtctgctgtgttc
caccagaaggctgagcagttcctgtcgggagtggatgcctggtgcaagatgtgcagtgaa
ggtggtctgccatccgagatgcaagacctagagctggcaatccaccaccaccagaccttg
tatgagcaggtgacccaagcctacacagaggtcagccaggatggcaaagcactacttgat
gtgctgcagcggcccctgagccctgggaactccgaatccctcacggccacagccaactac
tccaaggcagtgcaccaggtgctggacgtggtgcatgaggtgttacatcaccagcgacgg
ctggagagcatctggcagcaccgcaaggtgcggctccaccagcggctgcagctctgcgtc
ttccagcaggatgtacagcaggtgttggactggattgaaaaccatggtgaggcctttctc
agcaaacacactggagttgggaagtccctacatcgagcccgggccctgcagaagaggcat
gatgactttgaagaggtggctcagaatacgtacaccaatgcggacaagctcctagaagca
gcagagcagttggctcagacgggggaatgtgaccccgaggagatctacaaggcagctcga
cacctggaggtgcgcatccaagacttcgtgcgcagggtggagcagcggaagcttctcctg
gacatgtctgtttccttccacacacacaccaaagagttgtggacatggatggaagacctt
cagaaggagatgttggaggatgtctgtgcagattctgtggatgcagtccaggaactgatc
aagcagttccagcagcagcagaccgccactctagatgccacactcaatgtcatcaaggaa
ggcgaagaccttatccagcagctcaggtcagcgcctccctccctcggggagcccagcgag
gccagggactcggctgtgtccaacaacaaaacaccccacagcagctccatcagccacatc
gagtcggtcctgcagcagcttgatgatgcccaggtgcagatggaggagctgttccacgag
cggaagatcaagctggacatcttcctgcaactgcgcatctttgagcagtacaccatcgag
gtgacagcagagctagacgcctggaatgaagacttgcttcggcagatgaatgacttcaac
acagaggacctaaccctggcagaacagcggctgcagcgccacacagaacggaagctagcc
atgaacaacatgacctttgaggttatccagcagggacaggatctgcaccagtacatcacg
gaggtccaggcatcaggaattgagttgatctgtgaaaaagacattgatctggcagcccag
gtgcaagagttattggaatttctccatgagaagcagcatgaattggagctcaatgcagag
cagactcataagcggctagagcagtgcctccaattacgtcacctccaggctgaagtcaaa
caggttctgggatggatccgcaatggagagtcaatgctcaacgccagcctggtcaatgcc
agctctttgtcggaagcagagcagctgcagcgggagcacgagcagttccaactggccatc
gagtccctctttcatgccacttccttgcagaagacgcaccagagtgccctgcaggtacag
cagaaagccgaggtgctgctccaggccggccactacgatgccgatgccatccgggaatgt
gctgagaaggtggccctccactggcagcagctcatgctgaagatggaagaccggctaaaa
ttggtcaatgcctctgtggccttttacaaaacttctgaacaggtgtgtagtgtcctggag
agcttagagcaagaataccggagagatgaggactggtgtggtggacgagataagctgggg
ccagcagcagagatcgaccatgtcattcccctcatcagcaaacatttggaacaaaaggag
gcctttcttaaggcctgcaccctggctcggcggaatgctgaggtgtttctcaagtacatc
cacaggaacaacgtcagcatgcccagtgtcgccagccacactcggggacccgagcaacaa
gtgaaagccatcctgagtgagctcctgcagagggagaatcgcgtgctgcatttctggacc
ttgaagaagcggcggttagaccaatgccagcaatatgtggtgttcgagcgcagcgctaag
caggcgcttgactggatccaagaaacaggtgaattttacctctcaacacatacctccact
ggagagaccacagaggagactcaggaactgctgaaagaatatggggaattcagggtgcct
gccaagcaaacaaaggagaaggtgaagcttctgattcagctggccgatagctttgtggaa
aaaggccacattcatgccacggagataaggaaatgggtgaccacggtggacaagcactac
agagatttctccctgaggatgggaaagtaccgatactcactggagaaagccctaggagtc
aacacagaggataataaggacctggagctggatattatcccagcaagcctttcggatcgg
gaggtcaagctgcgggacgccaaccacgaagtcaatgaagagaagcggaagtcagcccgg
aagaaagaatttattatggctgaactactccagacagagaaggcttatgtaagggatttg
catgagtgcttagagacctacctgtgggaaatgaccagtggtgtggaggagatcccccct
gggatcctcaataaagagcatatcatctttggcaacatccaagagatctacgatttccat
aacaacatcttcctcaaagagctggagaagtacgagcaactgcctgaggatgtgggacac
tgctttgttacctgggcagacaaatttcagatgtatgtcacctactgtaaaaacaagcct
gattccaaccagcttatcctggagcatgcgggcaccttctttgatgagatacaacagcgg
catggtctggccaactccatctcttcctacctaattaagcctgtccaaaggatcaccaaa
tatcaactgctcctgaaggaacttttaacttgctgtgaagaagggaaaggggagctcaag
gatggcctggaggtgatgctcagtgtcccaaagaaagccaatgatgccatgcatgtcagc
atgctggaagggttcgacgagaacctggatgtgcagggggagttgattctccaggatgcc
tttcaagtgtgggacccgaagtcgctgatccggaaggggcgggagcggcacttgttcctc
tttgagatctccttggtttttagcaaggagatcaaagattcttcaggacacacgaaatat
gtttacaagaacaagctactgacctcagagctgggtgtgaccgagcacgtggagggcgat
ccctgcaaattcgccttgtggtctgggcgcaccccatcctcagacaataaaacagtgctg
aaagcctccaacattgaaaccaagcaggagtggatcaagaacattcgagaagtgattcaa
gaaaggatcattcacctgaaaggagctttaaaggagccacttcagctccccaaaacacca
gccaaacagaggaacaatagtaagagggatggagtggaggatattgacagccagggggat
gggagcagccaaccagacaccatctccattgcttctaggacctctcagaacacagtggac
agtgacaagctctctggtggatgtgagctgacagtggtcctccaggacttcagtgcgggc
cacagcagtgagctgaccatccaggtggggcagacggtagagctgctggagcggcccagc
gagcggcctggttggtgtctggtccgtaccaccgaacggagcccgcccttggagggtctg
gtccccagcagcgccctgtgcatctcacactcccgaagcagcgtggagatggactgcttc
ttccccttggtgaaagatgcatactctcattcctcaagcgagaatggaggcaagtccgag
tccgtggccaacctgcaggcccagccctccctgaactccatccacagttccccgggtccc
aagcgctccaccaacactcttaagaagtggctgacgagtcctgtgcgtcggcttaacagc
gggaaggcagatggaaacatcaaaaagcagaagaaagttcgcgatggtcggaagagcttt
gacctgggatctcccaagcctggggatgaaacaacccctcagggagacagcgctgatgag
aagagcaagaaaggttggggtgaagatgagccggatgaagagtcacacacacccctccca
ccacctatgaagatttttgacaacgaccctacacaggatgaaatgtcctcctctttgcta
gcagcccggcaggcttccactgaagtacctactgctgcagaccttgtcaatgcaatagaa
aagttggtcaaaaacaagctgagtctagaaggaagctcataccgggggagcttgaaagac
cctgcaggctgcctgaatgaggggatggccccacccacacctcctaaaaacccagaagaa
gaacagaaagccaaggccctgagaggcaggatgtttgtcctgaatgagctggtacagaca
gagaaagactatgtcaaggatctgggcattgtggtggagggcttcatgaagagaatagaa
gaaaagggtgtccctgaggatatgcgaggaaaggacaaaatcgtgtttggaaatattcat
cagatttatgactggcataaggattttttcctggcggaactggaaaagtgtatccaggag
caagacagattggcacagctctttattaagcacgagcggaagctgcacatctacgtgtgg
tattgtcagaataagccgcgctcagagtacatcgttgctgagtatgacgcctactttgag
gaggtaaaacaggagataaatcagaggctgacactgagtgacttcctcatcaagcccatt
cagagaataacaaaataccagttgctcctcaaggacttcctgagatacagtgagaaggct
ggtttggagtgttcagatattgagaaagcagtggagttaatgtgccttgttcccaaacgc
tgcaatgacatgatgaatctaggacgtctgcagggctttgagggcactctgactgctcag
gggaagctgctgcagcaggacacattctatgtgatcgagctggatgcaggcatgcagtcc
cggaccaaagagaggcgcgtgttcctcttcgagcagattgtcatcttcagtgaactgctc
aggaagggatccctcacccctggctacatgttcaaaaggagcatcaagatgaattacttg
gtcctggaggagaatgtggacaatgatccctgcaagtttgcactcatgaacagagagact
tctgagagggttgttctgcaagccgccaacgctgacatccagcaggcctgggtgcaggac
atcaatcaagtcttagaaacacagcgagactttttgaatgcactgcaatcgcccattgag
tatcaacggaaagaaaggagcacagctgtgatgaggtctcaacctgccaggcttccccaa
gccagccccaggccctactcctctgttcctgcgggctcagagaagcccccaaagggctcc
agctataacccacctctgcctcccctgaagatatctacctccaatggcagtccagggttt
gaataccaccagcctggggacaagttcgaagccagcaagcagaacgacctgggaggctgc
aatgggacctcgtccatggccgtgatcaaagattactatgcactgaaggagaatgaaatc
tgtgtgagccaaggtgaggtggtccaggtcctcgccgtcaaccagcagaacatgtgtctg
gtgtaccagcctgccagcgaccattcccccgccgccgagggctgggtcccaggcagcatc
ctggcgcccctcaccaaagccacagcagcagaaagtagtgacgggagcatcaagaagtca
tgttcatggcatactctacgcatgagaaagcgggcggaagtggagaacacgggtaaaaat
gaagccacagggcctcgtaaacccaaggatattctgggcaacaaagtctctgttaaagag
acgaacagttccgaggaatcagagtgtgatgatcttgaccctaatactagcatggagatc
ttaaatccaaatttcatccaagaagtggccccagaattccttgtgcccttggtggatgtg
acctgcttgcttggggacacagtgatactgcagtgcaaagtctgtgggcggccaaagccc
accatcacttggaagggtccagaccagaacatccttgacactgataacagctcagccaca
tacacggtctcctcttgtgattctggagaaatcaccctgaagatctgtaatctgatgccc
caagacagtgggatttatacctgcatagcaacaaatgaccacgggaccacatcaacgtct
gcaacagtcaaagtgcaaggtgttccagcagcccctaaccgccccattgcccaggagaga
agctgcacctccgtgattctccgctggctgcccccctccagcacaggaaactgcactatt
tctggttacactgtggagtacagagaggaaggttctcagatctggcagcagtcagtggct
tcgaccttggacacttacctcgtcatcgaagaccttagtcccgggtgtccttatcagttc
agagtcagtgccagtaacccctggggaatcagccttcccagcgagccctcggagtttgtg
cgacttccagaatatgatgctgctgctgatggtgccaccatttcttggaaggaaaatttt
gactcagcttacactgagctgaatgaaattggaagaggccgtttctctatagtaaagaaa
tgcattcacaaagctacccgcaaagatgtggctgtgaaatttgttagcaaaaaaatgaag
aagaaagaacaggctgcccacgaggctgccctgcttcagcacctacagcacccccagtac
atcactctccatgacacctatgagtcccccacatcctacatcctgatcttggaactgatg
gatgatggccggctcttagactaccttatgaatcatgatgaactgatggaggaaaaagta
gctttctatatccgagacatcatggaggctctgcagtaccttcacaactgcagggttgca
catttggacataaagcctgaaaacctgctcattgacctacggattccagtgcctcgagtg
aagctcattgacttggaggatgctgtccagatctcgggtcacttccacattcaccacctg
ctggggaaccctgagtttgctgccccagaagtcattcaaggcatccccgtctccctgggg
acagacatctggagcatcggggttctgacatatgtcatgctgagtggggtctcccccttc
ttggatgagagcaaagaggagacatgtatcaacgtatgcagggtggatttcagcttcccc
catgaatacttctgtggtgtgagcaatgctgccagagatttcatcaatgtgatcttacag
gaagattttcggaggcggcccacagcagccacatgcttgcagcatccatggctgcagccc
cataatggcagctactctaagatccccctggacacctcccgcctagcatgcttcatagaa
cgtcgcaagcaccagaatgatgtgcggcctattcccaatgtcaagagctacattgtcaac
cgggtgaaccaagggacgtag
DBGET
integrated database retrieval system
